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  SIDE EFFECTS 5-HTP TYROSINE DOPA-GI UPSET ON STARTUP 1
 

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SIDE EFFECTS 5-HTP TYROSINE DOPA-GI UPSET ON STARTUP

   
 
Written by: Marty L. Hinz, MD
President Clinical Research
NeuroResearch Clinics, Inc.
Cape Coral, Florida USA Research Office
   
 
PATIENT HAND OUT
GI Upset on Start Up

  Side effects 5-HTP tyrosine dopa GI upset on startup: GI upset (98% of start up problems) and other problems that occur on the starting of serotonin and dopamine neurotransmitter precursors 5-HTP, tyrosine, levodopa, and cysteine can be managed properly and easily. With GI upset the typical scenario is that the person experiences GI upset with the first dose of serotonin and dopamine neurotransmitter precursors 5-HTP, tyrosine, levodopa, and cysteine. The GI upset then builds until day 3 at which point the person quits the serotonin and dopamine neurotransmitter precursors 5-HTP, tyrosine, levodopa, and cysteine.

  From our work we know that start up GI upset occurs in the people that are most depleted of serotonin and dopamine neurotransmitter molecules. These are the people who need 5-HTP, tyrosine, levodopa, and cysteine therapy the most. People who have recently (in the last 18 to 24 months) been on certain serotonin and dopamine drugs that deplete serotonin and dopamine neurotransmitter molecules can experience this problem at an increased rate. A nutrient poor diet can also contribute to this problem as well as other mechanisms of action.

  So how is this managed properly? FIRST you need to tell all people starting serotonin and dopamine neurotransmitter precursors 5-HTP, tyrosine, levodopa, and cysteine therapy, “If you have problems with upset stomach as you start the pills, quit the pills until you can get back into the office for instructions on how to manage the problem." Simply doing this will keep new people from dropping out of treatment if problems with GI upset are encountered.

  When a person returns complaining of GI upset or other start up problems the proper management is to simply cut back the dosing to one pill at bed time. Bedtime is when the person is ready to go to sleep not ready get in bed and read a book. If people with start up problems can take the one pill and fall asleep within 15 to 20 minutes the problems do not crop up. People who have experienced GI upset on start up have reported that eating one or two “soda crackers” before taking the pills at bed time also helps the problem, but we have no studies on this. After the person has had no symptoms for 3 to 4 days, add an additional

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pill at bedtime and continue to increase dosing in a similar manner until the person is on 4 pills at bed time then start adding one pill in the AM in a similar manner until the person is at the starting dose of 8 pills a day. Once the person is on 8 pills a day of the serotonin and dopamine neurotransmitter precursors 5-HTP, tyrosine, levodopa, and cysteine dosing can be titrated upward as per usual with the NeuroResearch serotonin and dopamine neurotransmitter precursors treatment protocols until therapeutic serotonin and dopamine neurotransmitter levels are established as verified by serotonin and dopamine urinary neurotransmitter testing in treatment of depression, anxiety, attention deficit ADD ADHD, etc., etc. and clinical observations. It generally takes 3 to 4 weeks to get people with serotonin and dopamine neurotransmitter levels up to the starting dose of 5-HTP, tyrosine, levodopa, and cysteine (8 pills a day).

  From the database where the incidence of GI upset on start up is 0.5%, although we have seen practices where the incidence is much higher, such as the practice of an addictionologist or practices that were using large amounts of drugs that had a propensity for depleting serotonin and dopamine neurotransmitter molecules such as reuptake inhibitors.

Side effects 5-HTP tyrosine dopa GI upset on startup

 
Side effects 5-HTP tyrosine dopa GI upset on startup
 
SIDE EFFECTS 5-HTP TYROSINE DOPA-GI UPSET ON STARTUP
 
SIDE EFFECTS

  In taking 5-HTP, tyrosine, levodopa, and cysteine there is no side effect that should require stopping on a permanent basis if managed properly. At the left links to management strategies and person hand outs relating to side effects.

 
 

Side effects 5-HTP tyrosine dopa GI upset on startup

 
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