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NeuroResearch Clinics relies exclusively on DBS Labs for urinary serotonin and dopamine neurotransmitter testing in natural treatment of disease. DBS Labs is directed by Tom Uncini, MD hospital based pathologist who is dual board certified in laboratory medicine. Dr. Uncini is the medical director of two hospital labs, University of Minnesota Medical Center Mesabi in Hibbing, MN and Cook Hospital in Cook, MN. Dr. Uncini is also on the faculty of the University of Minnesota Medical School. The urinary neurotransmitter testing produced by DBS Labs is of hospital caliber. Between Dr. Uncini and his lab manager there are over 50 years of hospital based laboratory experience.

  The experience and credentials of the people running DBS Labs stand in stark contrast to the other labs out there attempting to do urinary neurotransmitter testing. Other laboratories have no hospital based board certified laboratory medicine pathologist running the lab, no license to practice medicine, no hospital privilege affiliation, no clinic, no patients, and have never treated one patient in clinic. Yet some are holding out that they have the expertise to tell doctors how to treat their patients when the urinary neurotransmitter testing results are reported back to the doctor. This may explain why the testing results of these labs do not correlate when the same sample is run on split sample testing by DBS Labs and the non-MD lab. These non-MD labs are the labs that are recommending and inducing licensed medical doctors to get "baseline urinary neurotransmitter testing" prior to treatment even though there is no correlation between testing prior to and once taking amino acid precursors.

Pike Lake Duluth photo by Amy Gunthert  
 

Organic cation transporter neurotransmitter optimization-SPOTTING A BAD LABORATORY

Organic cation transporter neurotransmitter optimization-SPOTTING A BAD LABORATORY 1
Contact us or find a caregiver using this approach.
 

neurotransmitter testing-QUALITY ASSURANCE

Written by: Marty L. Hinz, MD
President Clinical Research
NeuroResearch Clinics, Inc.
Cape Coral, Florida USA Research Office
 
neurotransmitter testing-QUALITY ASSURANCE
 
   

TIPS FOR SPOTTING BAD neurotransmitter testing LABORATORY QUALITY ASSURANCE

  The quality assurance process in a medical laboratory, not directed by a hospital based board pathologist board certified in laboratory medicine, can be sloppy or easily mis-represented. So how can a doctor in a clinic know if the quality assurance in the laboratory reporting out medical results meets expected guidelines? One answer is to examine represents of the peer reviewed scientific medical literature as made by the lab  that the testing is based on in comparison to what the peer reviewed scientific medical literature actually says.

HINTS YOU HAVE neurotransmitter testing FROM A LAB WHOSE QUALITY ASSURANCE PROCESS NEEDS TO BE SCRUTINIZED

You may have laboratory quality assurance issues when:

1. When the lab consistently demonstrates that 5-HTP increases urinary serotonin levels there is a mis-representation of medical scientific literature by the lab and laboratory quality assurance needs to be scrutinized.

THE SCIENCE: There is no direct correlation between administration of 5-HTP and urinary serotonin levels the only correlation that exists is when the urinary serotonin phase of response is determined with varied 5-HTP dosing. If a lab tries to tell you that it can demonstrate a consistent elevation of serotonin with urinary neurotransmitter testing in the administration of 5-HTP, inaccurate results are being reported, the lab has miscalibrated lab reports, or equipment. 

2. If the lab claims that serotonin, dopamine, norepinephrine, or epinephrine found in the urine are neurotransmitters that were filtered at the glomerulous of the kidney and excreted into the urine there is a mis-representation of medical scientific literature by the lab and laboratory quality assurance needs to be scrutinized.

THE SCIENCE: Peer reviewed medical literature is clear, urinary serotonin, dopamine, norepinephrine, and epinephrine are not neurotransmitters that were filtered by the kidney and excreted into the urine they are neurotransmitters that were synthesized by the kidneys. There is no correlation between urinary neurotransmitter levels and neurotransmitter levels of the brain or peripheral circulation.

3. The lab recommends obtaining serotonin and dopamine baseline urinary neurotransmitter testing prior to treatment with 5-HTP, tyrosine, and/or dopa  there is a mis-representation of medical scientific literature by the lab and laboratory quality assurance needs to be scrutinized.

THE SCIENCE: Urinary serotonin and dopamine prior to treatment with 5-HTP, tyrosine, levodopa, and cysteine is in the "endogenous state". Once significant levels of 5-HTP, tyrosine, levodopa, and cysteine are given the urinary serotonin and dopamine are in the "competitive inhibition" state. Baseline urinary neurotransmitter testing in the endogenous state prior to administration of 5-HTP, tyrosine, levodopa, and cysteine has no correlation with testing performed once in the "competitive inhibition state" seen when taking 5-HTP, tyrosine, levodopa, and cysteine.

4. If the lab suggests that serotonin and dopamine urinary neurotransmitter testing correlates with peripheral and/or central nervous system serotonin and dopamine levels there is a mis-representation of medical scientific literature by the lab and laboratory quality assurance needs to be scrutinized.

THE SCIENCE: Urinary serotonin, dopamine, norepinephrine, and epinephrine are neurotransmitter molecules that are synthesized by the kidneys and have no correlation with central or peripheral serotonin and dopamine neurotransmitter levels.

5. The lab doesn't understand or determine "the three phases of serotonin and dopamine" in urinary neurotransmitter response to amino acid administration or claims there is a mis-representation of medical scientific literature by the lab and laboratory quality assurance needs to be scrutinized.

THE SCIENCE: As noted in the University of Minnesota Medical School paper the only correlation that exists between administration of 5-HTP, tyrosine, levodopa, and cysteine and serotonin and dopamine urinary neurotransmitter testing is the three phases of response when the 5-HTP, tyrosine, levodopa, and cysteine dosing is changed when two separate testing are obtained.

6. If the lab asserts that serotonin, dopamine, norepinephrine, or epinephrine cross the blood brain barrier there is a mis-representation of medical scientific literature by the lab and laboratory quality assurance needs to be scrutinized.

THE SCIENCE: Serotonin, dopamine, norepinephrine, and epinephrine neurotransmitter molecules do not cross the blood brain barrier. Despite the fact that this has been established for years, we continue to hear from doctors that there are labs recommending baseline urinary neurotransmitter testing who assert that the serotonin, dopamine, norepinephrine, and epinephrine neurotransmitter molecules cross the blood brain barrier, which they do not.

- neurotransmitter testing

- neurotransmitter testing-In depth

- neurotransmitter testing-Source of urinary neurotransmitters

- neurotransmitter testing-Blood brain barrier

- neurotransmitter testing-Collection time

- neurotransmitter testing-Quality control

- neurotransmitter testing-Quality assurance

- neurotransmitter testing-Reference ranges

- neurotransmitter testing-Flawed results

- neurotransmitter testing-Julia Ross

- neurotransmitter testing-Baseline testing

- neurotransmitter testing-3 phase dosing versus 3 phase response

 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

The University of Minnesota Medical School neurotransmitter testing paper.

FROM PEER REVIEWED LITERATURE

Curiously, 5-HTP did not exhibit a clear influence on urinary serotonin excretion when 5-HTP doses were compared to urinary serotonin excretion; however, a relationship was observed when alterations in 5-HTP dose were compared to alterations in urinary serotonin excretion.  The data indicate three, statistically discernible, components to 5-HTP responses, including inverse, no and direct relationships between urinary serotonin excretion and 5-HTP doses. 

Both stimulatory and inhibitory effects of dietary 5 HydroxyTryptophan and Tyrosine on urinary excretion of serotonin and dopamine in a large human population

George J. Trachte, Thomas Uncini and Marty Hinz, Department of Physiology and Pharmacology, University of MN Medical School

 
 

neurotransmitter testing-QUALITY ASSURANCE

neurotransmitter testing QUALITY ASSURANCE: THE LITERATURE

Both stimulatory and inhibitory effects of dietary 5 HydroxyTryptophan and tyrosine on urinary excretion of serotonin and dopamine in a large human population.

Department of Physiology and Pharmacology, University of MN Medical School Duluth, 1035 University Drive, Duluth, MN 55812, County Coroner etc

University of Minnesota Medical School Urinary neurotransmitter testing Paper #1 Full Text

  From the University of Minnesota Medical School paper; there is no correlation between dosing of 5-HTP administered and urinary neurotransmitter testing serotonin levels. The only correlation found was when 5-HTP dosing levels were changed then urinary neurotransmitter testing levels were compared leading to the finding that serotonin response with administration of 5-HTP exits is three distinct phases.

Curiously, 5-HTP did not exhibit a clear influence on urinary neurotransmitter testing in serotonin excretion when 5-HTP doses were compared to urinary neurotransmitter testing of serotonin excretion; however, a relationship was observed when alterations in 5-HTP dose were compared to alterations in urinary neurotransmitter testing of serotonin excretion.  The data indicate three, statistically discernible, components to 5-HTP responses, including inverse, no and direct relationships between urinary neurotransmitter testing of serotonin excretion and 5-HTP doses.

neurotransmitter testing-QUALITY ASSURANCE

 
 
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