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Depression 5-HTP L-dopa
Monoamine
Metabolism
The Monoamine Oxidase (MAO) and
Catecholamine-O-Methyl
Transferase (COMT) enzymes
metabolize serotonin and the
catecholamines, as illustrated
in the kidney in figure 4 bottom
left.12 The
implications are profound.
The levels of these two enzyme
systems are not static; they
fluctuate in response to
changing neurotransmitter
levels. When
neurotransmitter levels are
increased, enzymatic activity
also increases.
If you administer L-dopa or
5-HTP, the activity of MAO and
COMT increases due to the
increase in dopamine or
serotonin levels respectively.
The problem occurs when L-dopa
is administered without 5-HTP,
both dopamine and serotonin will
be subjected to increases in
metabolism by these two enzyme
systems. However,
serotonin will |
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not
experience an increase in production,
which leads to further depletion.
The same rule is true of 5-HTP
administered without the use of dopamine
precursors. The bottom line is
that the administration of 5-HTP or
L-dopa that is unopposed or improperly
balanced with the amino acid precursors
of the other system will deplete the
other system as a result of the
increased metabolism of MAO and COMT,
decreased synthesis, and uptake
competition (as covered in the next
section).
Depression 5-HTP L-dopa
Monoamine
Metabolism
Its no secret, NeuroResearch Clinics uses the nutrients 5-HTP, tyrosine, levodopa,
and cysteine to treat medical
patients in order to get these
results. Proper
use of these simple ingredients in
medical treatment is not simple.
From time to time a patient will
say, "Why do I want to take that, I
can go to a health food store and
buy it?" People off the street
buying in a health food store is
like going to an art store and
buying a bunch of oil paints then
going home and expecting to paint
like a mater artist even though
there was no previous painting
experience. These nutrients have
tremendous potential due to their
chemical properties. This potential
is only fully realized in the hands
of the trained professional using
neurotransmitter testing. Treatment
is not just giving a nutrient pill, it is the whole medical management approach doctors are trained in to insure that that treatment is on track in order to get symptoms under control.
he Peer Reviewed Research
of NeuroResearch Clinics
The neurotransmitter treatment research findings of NeuroResearch Clinics
have not been ignored. The University of
Minnesota Medical School is writing a series of
papers on the neurotransmitter testing research of NeuroResearch Clinics. The first of a series of papers by University of Minnesota Medical School based on the neurotransmitter testing research of NeuroResearch was published in "NeuroPsychiatric Disease and Treatment" May 1, 2009. Ingrid
Kohlstadt, MD of Johns Hopkins in her new
medical text book released February 7, 2009
included a chapter on depression written by
Marty L. Hinz, MD President Clinical
Research NeuroResearch Clinics outlining in
depth the proper use of amino acids and
neurotransmitter testing in treatment of
depression.
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