|
seen in the
treatment of elderly with reuptake
inhibitors who presumably have greater
cumulative life time effects from
neurotoxins and other events that cause
neuron damage. In the end these patients
need to have neurotransmitter levels
established that is much higher than can
be achieved with reuptake inhibitors
alone.
With
repeated insult more damage occurs which
is cumulative. When this damage is
at the point where the neurotransmitter
levels needed to control disease
symptoms can not be achieved with the
use of reuptake inhibitors alone from a
clinical stand point it appears that the
drug is not working. This may explain
why about 90% of adults treated with
reuptake inhibitors achieve results no
better than placebo.
The
bundle damage theory may also explain
why developed countries have a higher
rate of depression with the population
being exposed at a higher rate to
neurotoxins.
Since insult
exposure may be ongoing in patients with
depression, optimizing nutritional
status is important. Improving neuronal
ability to minimize and recover from
toxic insult form the basis of the
antioxidant nutrients. |
