Serotonin dopamine reuptake inhibitor depression ADHD

How Depression and ADHD Reuptake Inhibitors Deplete Serotonin and Dopamine Neurotransmitters

For people with depressed, ADHD, etc. synaptic serotonin and dopamine neurotransmitter levels are below the levels needed to prevent disease symptoms such as found in depression and ADHD.

serotonin dopamine depression ADHD drugs

Serotonin reuptake inhibitors, dopamine reuptake inhibitors, norepinephrine reuptake inhibitors, amphetamines, and cocaine block the reuptake of serotonin and dopamine neurotransmitter levels. This leads to a decrease in presynaptic serotonin and dopamine neurotransmitter levels (where the serotonin and dopamine neurotransmitter levels are safe from enzymatic breakdown). In the blocking of serotonin and dopamine neurotransmitter depression and ADHD reuptake inhibitor increases serotonin and dopamine neurotransmitter levels in the synapse and increases the probability that serotonin and dopamine neurotransmitters will experience enzymatic metabolism.

dopamine serotonin reuptake inhibitor deplete in depression and ADHD

Overtime, the net effect of enzymatic metabolism is the depletion of serotonin and dopamine neurotransmitter levels in the central nervous system. Serotonin and dopamine neurotransmitters do not cross the blood brain barrier. Therefore, the only way to increase central nervous system levels or to prevent the overall depletion of serotonin and dopamine neurotransmitters is to provide amino acid precursors, which cross the blood brain barrier and are able to be synthesized into serotonin and dopamine neurotransmitters.

Drugs that work with serotonin and dopamine neurotransmitter molecules, do not work if there are not enough serotonin and dopamine neurotransmitter molecules with which to work. Long term use of depression and ADHD drugs deplete serotonin and dopamine neurotransmitter levels in most people if proper amino acid precursors are not administered.

Serotonin, dopamine, norepinephrine, and epinephrine neurotransmitter molecules do not cross the blood brain barrier. The only way to increase central nervous system levels of serotonin and dopamine neurotransmitter levels is to provide amino acid precursors which cross the blood brain barrier. They will then be synthesized in the brain into serotonin and dopamine neurotransmitter molecules.

If you keep the system topped off with amino acids when using depression, ADHD, or other drugs that work with serotonin and dopamine neurotransmitter molecules will function optimally and the depression or ADHD patient will feel optimal.