Carbidopa

Carbidopa

  In giving levodopa carbidopa is used to treat problems of nausea associated with the use of levodopa. Carbidopa does not cross the blood brain barrier. Carbidopa blocks peripheral synthesis of both serotonin and dopamine, which results in serotonin and dopamine depletion. Peripheral neurotransmitter related problems are by far the largest grouping of side effects seen in Parkinson's Disease treatment. I have never seen any of these problems when treating with levodopa alone or in combination with 5-HTP. These problems appear to only occur when Carbidopa is added to treatment.

   The peripheral blocking of serotonin and dopamine synthesis by Carbidopa appears to also have significant effects on the hematologic system and the liver (as reflect in the occurrence of lab abnormalities). Proper management of these problems involves eliminating Carbilevodopa, which removes the problem of serotonin and dopamine depletion. A list of problems seen during Parkinson's Disease treatment with carbidopa includes:

• syncope

• hemolytic and non-hemolytic anemia

• thrombocytopenia

• pruritus

• paresthesia

• Hypotension

• Abnormalities in alkaline phosphatase

• Glossitis

• gait abnormalities

• numbness

• oculogyric crises

• urinary retention

• hot flashes

• phlebitis

• Henoch-Schonlein purpura

• leukopenia

• Back pain

• Increased sweating

• Asthenia (weakness)

• Abnormalities in SGOT (AST), SGPT (ALT)

• leg pain

• blepharospasm

• muscle twitching

• diplopia

• urinary incontinence

• sense of stimulation

• palpitation

• Decreased hemoglobin and hematocrit

• Angioedema

• Shoulder pain

• Alopecia

• Dysphagia

• Abnormalities in blood urea nitrogen (BUN),

• ataxia

• trismus

• peripheral neuropathy

• blurred vision

• hoarseness

• Agranulocytosis

• Upper respiratory infection

• Urticaria

• Muscle cramps

• Dark sweat

• Sialorrhea

• Abnormalities in Coombs test

• falling

• increased tremor

• flushing

• dilated pupils

• malaise

Carbidopa

Carbidopa-research

Carbidopa-research

Carbidopa-research

Carbidopa-research

Carbidopa-research

Carbidopa-research

Carbidopa-research

Carbidopa-research

Carbidopa-research

Carbidopa-research