WARNING:
Clinical Worsening and
Suicide Risk
The warning above is found
in the prescribing
information of virtually all
reuptake inhibitor
antidepressants.
Antidepressant
side
effects:
In
discussion
the
side
effects
of
antidepressant
drugs
one
is
left
thinking,
"Where
do I
start?".
On
the
"Antidepressants
list"
hyperlink
at
the
right
are
links
to
the
prescribing
information
for
a
number
of
reuptake
inhibitor
drugs.
In
reviewing
the
prescribing
information
each
drug
carries
between
15
and
35
pages
of
side
effects
and
warnings
listed.
An
overview
of
the
topic
looks
like
this:
-
The side effect of sexual dysfunction is list as occurring in 1 to 2% of patient. During the research leading up to this web site hundreds of patients who were taking reuptake inhibitor antidepressants were questioned closely and the incidence of sexual dysfunction was found to be over 50%.
-
These drugs are habit form (see the link to the right for more discussion)
-
These drugs deplete neurotransmitters making the cause of the problem worse.
-
The drugs can cause suicide to occur.
-
These drugs can make the disease they are treating worse.
-
These drugs are not effective if you define "not effective" as 93% of people taking these drugs getting relief of symptoms not better than a sugar pill.
A
SAMPLING
OF
ANTIDEPRESSANTS
SIDE
EFFECTS
Body
as a
Whole:
Infrequent:
Allergic
reaction,
chills,
face
edema,
malaise,
neck
pain;
rare:
Adrenergic
syndrome,
cellulitis,
moniliasis,
neck
rigidity,
pelvic
pain,
peritonitis,
sepsis,
ulcer.
Cardiovascular
System:
Frequent:
Hypertension,
tachycardia;
infrequent:
Bradycardia,
hematoma,
hypotension,
migraine,
postural
hypotension,
syncope;
rare:
Angina
pectoris,
arrhythmia
nodal,
atrial
fibrillation,
bundle
branch
block,
cerebral
ischemia,
cerebrovascular
accident,
congestive
heart
failure,
heart
block,
low
cardiac
output,
myocardial
infarct,
myocardial
ischemia,
pallor,
phlebitis,
pulmonary
embolus,
supraventricular
extrasystoles,
thrombophlebitis,
thrombosis,
varicose
vein,
vascular
headache,
ventricular
extrasystoles.
Digestive
System:
Infrequent:
Bruxism,
colitis,
dysphagia,
eructation,
gastritis,
gastroenteritis,
gingivitis,
glossitis,
increased
salivation,
liver
function
tests
abnormal,
rectal
hemorrhage,
ulcerative
stomatitis;
rare:
Aphthous
stomatitis,
bloody
diarrhea,
bulimia,
cardiospasm,
cholelithiasis,
duodenitis,
enteritis,
esophagitis,
fecal
impactions,
fecal
incontinence,
gum
hemorrhage,
hematemesis,
hepatitis,
ileitis,
ileus,
intestinal
obstruction,
jaundice,
melena,
mouth
ulceration,
peptic
ulcer,
salivary
gland
enlargement,
sialadenitis,
stomach
ulcer,
stomatitis,
tongue
discoloration,
tongue
edema,
tooth
caries.
Endocrine
System:
Rare:
Diabetes
mellitus,
goiter,
hyperthyroidism,
hypothyroidism,
thyroiditis.
Hemic
and
Lymphatic
Systems:
Infrequent:
Anemia,
leukopenia,
lymphadenopathy,
purpura;
rare:
Abnormal
erythrocytes,
basophilia,
bleeding
time
increased,
eosinophilia,
hypochromic
anemia,
iron
deficiency
anemia,
leukocytosis,
lymphedema,
abnormal
lymphocytes,
lymphocytosis,
microcytic
anemia,
monocytosis,
normocytic
anemia,
thrombocythemia,
thrombocytopenia.
Metabolic
and
Nutritional:
Frequent:
Weight
gain;
infrequent:
Edema,
peripheral
edema,
SGOT
increased,
SGPT
increased,
thirst,
weight
loss;
rare:
Alkaline
phosphatase
increased,
bilirubinemia,
BUN
increased,
creatinine
phosphokinase
increased,
dehydration,
gamma
globulins
increased,
gout,
hypercalcemia,
hypercholesteremia,
hyperglycemia,
hyperkalemia,
hyperphosphatemia,
hypocalcemia,
hypoglycemia,
hypokalemia,
hyponatremia,
ketosis,
lactic
dehydrogenase
increased,
non-protein
nitrogen
(NPN)
increased.
Musculoskeletal
System:
Frequent:
Arthralgia;
infrequent:
Arthritis,
arthrosis;
rare:
Bursitis,
myositis,
osteoporosis,
generalized
spasm,
tenosynovitis,
tetany.
Nervous
System:
Frequent:
Emotional
lability,
vertigo;
infrequent:
Abnormal
thinking,
alcohol
abuse,
ataxia,
dystonia,
dyskinesia,
euphoria,
hallucinations,
hostility,
hypertonia,
hypesthesia,
hypokinesia,
incoordination,
lack
of
emotion,
libido
increased,
manic
reaction,
neurosis,
paralysis,
paranoid
reaction;
rare:
Abnormal
gait,
akinesia,
antisocial
reaction,
aphasia,
choreoathetosis,
circumoral
paresthesias,
convulsion,
delirium,
delusions,
diplopia,
drug
dependence,
dysarthria,
extrapyramidal
syndrome,
fasciculations,
grand
mal
convulsion,
hyperalgesia,
hysteria,
manic-depressive
reaction,
meningitis,
myelitis,
neuralgia,
neuropathy,
nystagmus,
peripheral
neuritis,
psychotic
depression,
psychosis,
reflexes
decreased,
reflexes
increased,
stupor,
torticollis,
trismus,
withdrawal
syndrome.
Respiratory
System:
Infrequent:
Asthma,
bronchitis,
dyspnea,
epistaxis,
hyperventilation,
pneumonia,
respiratory
flu;
rare:
Emphysema,
hemoptysis,
hiccups,
lung
fibrosis,
pulmonary
edema,
sputum
increased,
stridor,
voice
alteration.
Skin
and
Appendages:
Frequent:
Pruritus;
infrequent:
Acne,
alopecia,
contact
dermatitis,
dry
skin,
ecchymosis,
eczema,
herpes
simplex,
photosensitivity,
urticaria;
rare:
Angioedema,
erythema
nodosum,
erythema
multiforme,
exfoliative
dermatitis,
fungal
dermatitis,
furunculosis;
herpes
zoster,
hirsutism,
maculopapular
rash,
seborrhea,
skin
discoloration,
skin
hypertrophy,
skin
ulcer,
sweating
decreased,
vesiculobullous
rash.
Special
Senses:
Frequent :
Tinnitus;
infrequent:
Abnormality
of
accommodation,
conjunctivitis,
ear
pain,
eye
pain,
keratoconjunctivitis,
mydriasis,
otitis
media;
rare:
Amblyopia,
anisocoria,
blepharitis,
cataract,
conjunctival
edema,
corneal
ulcer,
deafness,
exophthalmos,
eye
hemorrhage,
glaucoma,
hyperacusis,
night
blindness,
otitis
externa,
parosmia,
photophobia,
ptosis,
retinal
hemorrhage,
taste
loss,
visual
field
defect.
Urogenital
System:
Infrequent:
Amenorrhea,
breast
pain,
cystitis,
dysuria,
hematuria,
menorrhagia,
nocturia,
polyuria,
pyuria,
urinary
incontinence,
urinary
retention,
urinary
urgency,
vaginitis;
rare:
Abortion,
breast
atrophy,
breast
enlargement,
endometrial
disorder,
epididymitis,
female
lactation,
fibrocystic
breast,
kidney
calculus,
kidney
pain,
leukorrhea,
mastitis,
metrorrhagia,
nephritis,
oliguria,
salpingitis,
urethritis,
urinary
casts,
uterine
spasm,
urolith,
vaginal
hemorrhage,
vaginal
moniliasis.
Postmarketing
Reports:
Voluntary
reports
of
adverse
events
in
patients
taking
have
been
received
since
market
introduction
and
not
listed
above
that
may
have
no
causal
relationship
with
the
drug
include
acute
pancreatitis,
elevated
liver
function
tests
(the
most
severe
cases
were
deaths
due
to
liver
necrosis,
and
grossly
elevated transaminases
associated
with
severe
liver
dysfunction),
Guillain-Barré
syndrome,
toxic
epidermal
necrolysis,
priapism,
syndrome
of
inappropriate
ADH
secretion,
symptoms
suggestive
of
prolactinemia
and
galactorrhea;
extrapyramidal
symptoms
which
have
included
akathisia,
bradykinesia,
cogwheel
rigidity,
dystonia,
hypertonia,
oculogyric
crisis
which
has
been
associated
with
concomitant
use
of
pimozide;
tremor
and
trismus;
status
epilepticus,
acute
renal
failure,
pulmonary
hypertension,
allergic
alveolitis,
anaphylaxis,
eclampsia,
laryngismus,
optic
neuritis,
porphyria,
ventricular
fibrillation,
ventricular
tachycardia
(including
torsade
de
pointes),
thrombocytopenia,
hemolytic
anemia,
events
related
to
impaired
hematopoiesis
(including
aplastic
anemia,
pancytopenia,
bone
marrow
aplasia,
and
agranulocytosis),
and
vasculitic
syndromes
(such
as
Henoch-Schönlein
purpura).
There
has
been
a
case
report
of
an
elevated
phenytoin
level
after
4
weeks
and
phenytoin
coadministration.
There
has
been
a
case
report
of
severe
hypotension
when
was
added
to
chronic
metoprolol
treatment. |
