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Antidepressant
effectiveness
elderly:
Elderly
is
defined
as
65
years
of
age
an
older.
The
results
of
recent
double
blind
placebo
controlled
studies
of
antidepressants
in
the
elderly
reveal
that
antidepressant
drugs
are
no
more
effective
than
a
sugar
pill
in
relieving
symptoms
of
depression.
In
fact,
a
sugar
pills
is
superior
to
giving
people
65
years
of
age
and
older
antidepressants
since
a
sugar
pill
is
just
as
effective,
costs
less,
and
has
much
fewer
side
effects.
The
following
are
some
of
the
recent
studies
performed
in
this
area.
Full text
elderly study 1
study 1:
Randomized placebo controlled depression study, treatment with
serotonin depression reuptake inhibitor
Celexa (Citalopram) 10 mg to 40 mg per day in people
suffering with depression 75 years old and older, N = 174.
Conclusion: "In the oldest group of
community-dwelling people suffering with depression to be studied to date,
depression medication was not more effective than placebo for
the treatment of depression."
Full text
elderly study 2
study 2:
Randomized double blind placebo controlled 12 week
depression study, treatment with serotonin depression reuptake inhibitor Lexapro (escitalopram) 10
mg to 20 mg per day in people suffering with depression over 60 years old, N =
264. Conclusion: "serotonin
depression reuptake
inhibitor Escitalopram
depression treatment was not significantly different from placebo
treatment on the primary depression efficacy measure.."
Full text
elderly study 3
study 3:
Randomized double blind placebo controlled 8 week
depression study,
treatment with serotonin depression reuptake inhibitor Lexapro (escitalopram) 10 mg per
day or serotonin depression reuptake inhibitor Prozac (fluoxetine)
20 mg per day in people suffering with depression in the study were 65 to 93 years old, N = 517.
Conclusion: "Both serotonin
depression reuptake
inhibitor escitalopram and
serotonin depression reuptake inhibitor
fluoxetine were well tolerated by elderly people
suffering with depression with MDD (major depressive disorder). Neither demonstrated
superior depression efficacy on primary endpoint versus placebo."
Full text
elderly study 4
study 4:
Randomized double blind placebo controlled 8 week
depression study, treatment with serotonin depression reuptake inhibitor Zoloft (sertraline) 50 mg
per day versus placebo in people suffering with
depression with depression over 60 years old, N
= 371. Conclusion: Only 10% of people
suffering with depression
taking serotonin depression reuptake inhibitor Zoloft (45% got better) showed results better
when compared to placebo (35% got better). 90% of
people suffering with depression taking Zoloft in this study got results no
better than placebo.
Full text
elderly study 5
study 5:
Depression participants (age
65 and older) were openly treated
with serotonin depression reuptake inhibitor sertraline (Zoloft) and then randomized into a double-blind, placebo
controlled depression continuation / maintenance
depression study of
recurrence of depression (about 2
years duration), N = 113. Drug depression dosage was maintained at
levels that achieved remission. Conclusion:
"No significant difference between the serotonin
depression reuptake inhibitor sertraline and
placebo groups was found in the proportion of
recurrences."
Abstract of elderly study 6
study 6: 6
week double blind placebo control depression study of depression
with serotonin depression reuptake inhibitor Prozac
versus placebo in people suffering with depression over 60
years old, N = 671. Conclusions: "..overall
depression
response (43.9% vs. 31.6%, p = .002) and
depression
remission
(31.6% vs. 18.6%, p < .001) rates." 87.3%
of elderly people suffering with depression
over 60 years old treated for
depression with serotonin depression reuptake inhibitor Prozac
can expect depression response that is no better than
placebo and 87.0% of people suffering with depression over 60
years old treated with serotonin depression reuptake inhibitor Prozac can expect
remission of depression symptoms no better than placebo based on this
depression study.
Abstract of elderly study 7
study 7: Double blind
placebo controlled randomized depression study of serotonin
depression reuptake inhibitor Prozac (fluoxetine)
versus placebo in treatment of depression in people
suffering with Alzheimer, N = 41. Conclusion: "serotonin
depression reuptake inhibitor Fluoxetine
treatment for depression in AD did not differ
significantly from depression treatment with placebo."
Full text
elderly study
8
study 8:
Randomized double blind placebo controlled 3 way
depression study
of serotonin depression reuptake inhibitor Prozac (fluoxetine) versus
serotonin norepinephrine depression reuptake inhibitor Effexor
(venlafaxine) versus placebo in the treatment of
depression in the elderly with a mean age of 71 years, N
= 300. Conclusion: "In this study,
there was no significant difference in efficacy among
placebo, serotonin norepinephrine depression reuptake inhibitor venlafaxine, and
serotonin depression reuptake inhibitor fluoxetine for the treatment
of depression."
ANTIDEPRESSANTS
EFFECTIVENESS
ELDERLY |
