5-HTP with tyrosine, 5HTP serotonin dopamine depression ADHD

The precursor of serotonin is 5-HTP aka 5HTP or 5 HTP. The precursors of dopamine tyrosine aka L-tyrosine, and L-dopa aka dopa. Taking these precursors is so safe that they are available in the United States over the counter without a prescription. A unique chemical property of 5-HTP aka 5HTP or 5 HTP and L-dopa aka dopa is that they are synthesized by the body to serotonin and dopamine neurotransmitter molecules without biochemical feed back regulation. There virtually no inhibition of serotonin and dopamine synthesis meaning the more 5-HTP aka 5HTP or 5 HTP and L-dopa aka dopa you give the more serotonin and dopamine you get in you system. Based on our work testing urinary serotonin and dopamine neurotransmitter levels we know that 5-HTP aka 5HTP or 5 HTP and L-dopa aka dopa has the ability to establish serotonin and dopamine levels in the body far higher than is needed to relieve symptoms of any of disease such as depression, ADHD, etc.

Common thinking in medicine is serotonin and/or dopamine neurotransmitter levels that are low cause disease such as depression, ADHD, etc. Yet here in the hands of every American is the very things needed to establish serotonin and dopamine neurotransmitter levels as high as we want 5-HTP aka 5HTP or 5 HTP and L-dopa aka dopa. Prior to the start of this research project in 1997 there were no formal studies showing 5-HTP aka 5HTP or 5 HTP and L-dopa aka dopa were truly effective in treatment of disease such as depression, ADHD, etc. To the contrary all previous studies have not shown effectiveness of 5-HTP aka 5HTP or 5 HTP and L-dopa aka dopa or were inconclusive at best. The question then is, "Why have 5-HTP aka 5HTP or 5 HTP and L-dopa aka dopa never been formally proven effective in the treatment of depression, ADHD, and a number of other diseases in scientific studies?" The answer is that dosing needs of 5-HTP aka 5HTP or 5 HTP and L-dopa aka dopa to be individualized, 5-HTP aka 5HTP or 5 HTP and L-dopa aka dopa needs to be used in proper balance and 5-HTP aka 5HTP or 5 HTP and L-dopa aka dopa needs to be used in proper amounts at which point 5-HTP aka 5HTP or 5 HTP and L-dopa aka dopa work very well."

PROTOCOL OVERVIEW

The natural protocols of NeuroResearch using 5-HTP aka 5HTP or 5 HTP , tyrosine aka L-tyrosine, and L-dopa aka dopa are highly effective in getting patients off serotonin and dopamine neurotransmitter depression and ADHD drugs that work with serotonin and dopamine. 5-HTP aka 5HTP or 5 HTP , tyrosine aka L-tyrosine, and L-dopa aka dopa are effective keeping drugs working especially in weight loss, depression, ADHD, and all other diseases where drugs that work with serotonin and dopamine are prescribed. 5-HTP aka 5HTP or 5 HTP , tyrosine aka L-tyrosine, and L-dopa aka dopa excels as an alternative treatment to prescription drugs that work with serotonin and catecholamines (dopamine, norepinephrine, and epinephrine). Unlike depression and ADHD prescription drugs that do nothing to increase neurotransmitter levels of serotonin and dopamine in the brain and actually deplete the neurotransmitter levels of serotonin and dopamine in most patients, the NeuroResearch using balanced 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa increases the neurotransmitter levels of serotonin and dopamine in the brain to the point where relief of symptoms is experienced.

These 5-HTP aka 5HTP or 5 HTP , tyrosine aka L-tyrosine, and L-dopa aka dopa protocols are highly effective but only in the hands of those that know how to use the 5-HTP aka 5HTP or 5 HTP , tyrosine aka L-tyrosine, and L-dopa aka dopa. If the established 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa protocols are followed we have seen 100% relief of depression, fibromyalgia, ADHD, migraine headaches, anxiety, panic attacks, obsessive compulsive disorder, phobias, and other diseases. symptoms.

Taking the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa is not like taking an aspirin where you take a pill and feel better in one half hour. It takes 3 to 5 days once the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa are started for maximum results to be seen. In patients that has experienced relief of depression, ADHD, etc. symptoms and the symptoms return it might be from missing one or more doses of pills. From the patient's perspective it appears that the pills have quit working when the real problem is missing pills.

These results are only obtained by following the 5-HTP aka 5HTP or 5 HTP , tyrosine aka L-tyrosine, and L-dopa aka dopa protocols. If the dosing of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa is not adjusted properly or if urinary serotonin and dopamine neurotransmitter testing is not obtained when indicated the patient may be left in a state with no relief of symptoms and only a bunch of medical bills to show for it.

Tyrosine aka L-tyrosine and L-dopa aka dopa deplete the sulfur amino acids when this happens glutathione and a host of other things are depleted or not synthesized properly. A sulfur amino acid must be given in proper amounts when using tyrosine aka L-tyrosine and/or L-dopa aka dopa. The top link to the right notes loss of "total glutathione" in Parkinson patients treated with L-dopa aka dopa. We have chosen the sulfur amino acid cysteine which is the least expensive of all the sulfur amino acids. Daily dosing of the chosen sulfur amino acid needs to be 4,500 mg per day, This dosing recommendation was arrived at through objective observation with data base analysis.

PAST STUDIES OF 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine AND L-dopa aka dopa

Using the urinary serotonin and the dopamine neurotransmitter approach invented by NeuroResearch Clinics, Inc. in 2001 we now know the reason 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine and L-dopa aka dopa has not proven effective in previous formal studies relates primary to flaws in the design of these serotonin and dopamine studies.

First, in looking at the dosing needs of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa in a large group of patients the individual dosing needs vary on a huge scale with some patients needing very high or very low dose of 5-HTP aka 5HTP or 5 HTP or L-dopa aka dopa in conjunction with very high or very low dose of the other simultaneously. Most of the previous studies simply gave a specific dose of one precursor of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa and looked for results.

The second consideration is that 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa need to be in balance with each other for proper results. This fact takes on many considerations. In working with 5-HTP aka 5HTP or 5 HTP and L-dopa aka dopa more is not always better, too much of one or too little of the other can lead to no relief of symptoms. The balance of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa has to be just right to get the serotonin and dopamine neurotransmitter levels just right.

N-Acetyl-tyrosine aka L-tyrosine IS NOT

AN EFFECTIVE PRECURSOR OF DOPAMINE

N-acetyl-tyrosine aka L-tyrosine (NAT) is synthesized from tyrosine aka L-tyrosine. The equilibrium of the chemical reaction lies far toward NAT, meaning very little NAT is converted to tyrosine aka L-tyrosine (the reaction that is needed if NAT is to serve as a precursor of L-dopa aka dopa). This fact has been known in medicine for years. The practical knowledge comes from the study of kidney dialysis patients who need tyrosine aka L-tyrosine replacement after dialysis. In kidney dialysis when N-acetyl-tyrosine aka L-tyrosine is administered, there are no significant increase in tyrosine aka L-tyrosine levels detected.

PHENYLALANINE NOT OPTIMAL

Phenylalanine is the precursor of tyrosine aka L-tyrosine, as such it is a better precursor than NAT. The problem with phenylalanine is it is too far up the chemical pathway to be a predictable precursor for neurotransmitter synthesis. It is shuttled to other pathways and does not provide predictable clinical results. For those that attempt to use phenylalanine or N-acetyl-tyrosine aka L-tyrosine as a dopamine precursor the question is, "Why?" When the effective precursors 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa are readily available.

NeuroResearch continuing medical education

5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, AND L-dopa aka dopa DEPLETE DOPAMINE AND SEROTONIN IF NOT GIVEN IN PROPER BALANCE

Based on the research of NeuroResearch Clinics we realized in 1999 that using only 5-HTP aka 5HTP or 5 HTP depletes dopamine, and using only L-dopa aka dopa depletes serotonin. So what does this look like from a clinical stand point when serotonin or dopamine become depleted? If serotonin or dopamine becomes too low the effects of L-dopa aka dopa or 5-HTP aka 5HTP or 5 HTP respectively will no longer be seen (they quit working).

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APPROACHES TO THERAPY WITH 5-HTP aka 5HTP or 5 HTP, TYROSINE aka L-tyrosine, AND L-DOPA aka dopa

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With regards to dosing of 5-HTP aka 5HTP or 5 HTP tyrosine aka L-tyrosine AND L-dopa aka dopa:

ONE SIZE DOES NOT FIT ALL

Simply placing patients on a fixed dosing of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, or L-dopa aka dopa for many weeks without relief of symptoms is a waste of money and causes patients to needlessly suffer, patients need to have weekly adjustments of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, or L-dopa aka dopa until symptoms are under control.

Individualized dosing of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa needs to be established for each patient in order for proper electrical firing of the serotonin and dopamine neurons to be established. This in turn will lead to relief of symptoms.

All too often we see care givers who continue the same dose of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, or L-dopa aka dopa after one week of treatment in cases where there is no relief of symptoms disease such as depression, ADHD, etc. Continuing patients on a dosing level of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa that does not give relief of symptoms in one week will not provide relief of symptoms with further time.

Not ordering serotonin and dopamine urinary neurotransmitter testing for patients not responding to treatment on the level 3 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing fails to offer patients the benefits that urinary serotonin and dopamine neurotransmitter testing has to offer. This leaves many patients, who should be symptom free by taking 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, or L-dopa aka dopa with symptoms.

Therapy with 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa is optimally effective only when each individual patient’s dosing needs is established. In patients that are not properly responding to adjustments in the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing this involves proper adjustment of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa doses and ordering laboratory urinary serotonin and dopamine neurotransmitter testing when indicated.

SEE YOUR PATIENTS WEEKLY

There are occasional patients who report complete relief of symptoms of disease such as depression, ADHD, etc. within hours of starting 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa. Many patients with depression, ADHD, etc. obtain relief of symptoms in the first week or two (on the level 1 or level 2 dosing of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa).

On the other end of the spectrum are those patients who need 4 to 6 urinary serotonin and dopamine neurotransmitter tests to obtain relief of symptoms (after no relief of symptoms on level 3 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing for one week). It is critical to see patients weekly since it will take 2 to 3 months for relief of symptoms of disease such as depression, ADHD, etc. in the most difficult cases. If you see these patients every 2 to 4 weeks while adjusting 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa, it may take 6 to 8 months for relief of symptoms of depression, ADHD, etc. to be obtained in some patients. Most patients with depression, ADHD, etc. will drop out of treatment before that happens.

ORDERING TESTING WHEN INDICATED

While urinary serotonin and dopamine neurotransmitter testing can be ordered by the care giver at any point in treatment, baseline urinary serotonin and dopamine neurotransmitter testing has no correlation with the serotonin or dopamine neurotransmitter phase once the patient is taking 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa.

For patients not experiencing relief of symptoms on the level 3 dosing after one week, a urinary serotonin and dopamine neurotransmitter test should be ordered in order to chart a future treatment course with the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa leading to relief of symptoms with disease such as depression, ADHD, etc.

Based on the review of tens of thousands of urinary serotonin and dopamine neurotransmitter tests, it is a waste of time and money to attempt to further regulate 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing without obtaining a urinary serotonin and dopamine neurotransmitter test once the patient has been on level 3 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing for one week with no relief of symptoms.

ADJUSTING 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine AND L-dopa aka dopa PROPERLY

In adult patients being treated for diseases such as depression, ADHD, etc. other than obesity, Restless Leg Syndrome, or Parkinsonism - the recommendation is to increase the 5-HTP aka 5HTP or 5 HTP and tyrosine aka L-tyrosine dosing weekly until relief of symptoms are obtained or until the level 3 dosing is in place - at which point, if relief of symptoms have not been obtain after one week, a urinary serotonin and dopamine neurotransmitter test should be ordered. It is not uncommon with the inexperienced care giver that the patient is left on level 1 or level 2 5-HTP aka 5HTP or 5 HTP and tyrosine aka L-tyrosine dosing for prolonged periods of time while relief of symptoms have not been obtained. This approach makes no sense, after the first week additional time will not facilitate relief of symptoms. The effects of and response to 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa is like a light switch. “It is on or off”. If relief of symptoms is not obtained in one week (at any given 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing level), additional time on that dosing level will not lead to relief of symptoms. The individual dosing needs of the patient leading to relief of symptoms needs to be established by properly adjusting the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing in a timely manner and ordering urinary serotonin and dopamine neurotransmitter testing when indicated. In patients not receiving relief of symptoms one week after the level 3 dosing is prescribed, a urinary serotonin and dopamine neurotransmitter test should be promptly ordered.

IN PATIENTS WHO HAVE NOT EXPERIENCED RELIEF OF SYMPTOMS AFTER ONE WEEK ON A GIVEN DOSING OF 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine AND L-dopa aka dopa:

Ø Failure to increase 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing to level 3 if needed is not optimal treatment for depression, ADHD, etc.

Ø Failure to order urinary serotonin and dopamine neurotransmitter testing when the patient has been on the level 3 dosing for one week without relief of depression, ADHD, etc. symptoms is not optimal treatment.

The difference between properly adjusting 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa and ordering urinary serotonin and dopamine neurotransmitter testing and simply starting patients with adjusting analogous to:

“Treating patients properly and simply playing around with 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa.”

ONE SIZE DOES NOT FIT ALL

Care givers can prescribe 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa for numerous reasons. When the goal of treatment is relief of symptoms, the patient should be seen weekly and the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing should be adjusted weekly until symptoms of depression, ADHD, etc. are under control. If after 21 days of treatment the patient still has not received relief of symptoms of depression, ADHD, etc. on level 3 dosing, urinary serotonin and dopamine neurotransmitter testing should be obtained in order to plot a proper individualized course of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing leading to relief of symptoms.

The problem with attempts at 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa therapy prior to our research project is still a problem with many of the “other approaches” today. “Some patients get better, many do not.” Optimal relief of symptoms in patients requires proper adjusting of the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing in a timely manner and ordering urinary serotonin and dopamine neurotransmitter testing when indicated.

DOING IT RIGHT.

DON’T LET YOUR PATIENTS SUFFER WITH SYMPTOMS.

The most common mistake we have seen with care givers treating patients for depression, ADHD, etc. is to start 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa and leave the patient on the same dose longer than one week (in some cases, several weeks or months) when there is no relief of symptoms at the end of one week. Patients who do not receive relief of symptoms after one week of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa at a given dose will not obtain relief of their symptoms by prolonging the time that they stay at their current dosing level.

It takes 3 to 5 days for the maximum results of starting or changing the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing to be seen. When the patient returns to clinic after one week on a given 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing, the question to ask IS NOT, “How were your symptoms last week?” The question should be, “How were you symptoms yesterday?” If the patient’s symptoms were not under control for most of the previous week, but were under control “yesterday” (the day before the visit), you can leave the patient on the current 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing and see the patient back in one week to ensure symptoms are under control

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Group Dosing Needs

BEYOND THE KEY HOLE

In the past looking 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa was like looking at the other side of a door through a key hold. We see something there but results when applied to group treatment were not effective or consistent. In retrospect, the problem was that we did not understand the dosing ranges needed in optimal group treatment for optimal relief of symptoms. The individual dosing needs of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa to affect relief of symptoms varies on a huge level in group treatment. Unless you are prepared to properly establish each patient’s individual 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing as needed, you will not obtain optimal results with your patients.

5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa DOSING RANGES NEEDED

FOR OPTIMAL GROUP TREATMENT

Individual 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing needs vary on a huge scale. The following are the dosing ranges for individual 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa components that are needed for optimal individual results:

Ø 5-HTP aka 5HTP or 5 HTP 37.5 to 3,000 mg per day

Ø tyrosine aka L-tyrosine 375 to 12,000 mg per day

Ø L-dopa aka dopa 120 to 12,000 mg per day.

It is important that 5-HTP aka 5HTP or 5 HTP be used in proper balance with the dopamine precursors. DO NOT use only one 5-HTP aka 5HTP or 5 HTP, L-dopa aka dopa, or tyrosine aka L-tyrosine you will deplete serotonin and dopamine neurotransmitter levels.

ESTABLISHING THE INDIVIDUAL 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa DOSING IN TREATMENT

The goal of treatment is the optimal relief of symptoms. In order to affect symptoms, each patient needs to have the serotonin and catecholamine precursors 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa established in an individualized dosing level. The approach is:

Ø Start all patients on level 1 treatment and see them back in one week. If symptoms are not under control, adjust the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa to levels 2 or 3, at which point most patients will have found relief of symptoms.

Ø If on level 3 the symptoms are not under control obtain a urinary serotonin and dopamine neurotransmitter test and follow the recommendations until symptoms resolve.

Ø Do not prescribe over 900 mg per day of 5-HTP aka 5HTP or 5 HTP or 5,000 mg per day of tyrosine aka L-tyrosine without urinary serotonin and dopamine neurotransmitter testing establishing the need to do so.

MISSING THE BOAT --- DO NOT USE ONLY 5-HTP aka 5HTP or 5 HTP

Practicing medicine is a serious responsibility. The goal is to get diseases such as depression, ADHD, etc. and their symptoms under control as soon as possible in all patients.

If you are not using urinary serotonin and dopamine neurotransmitter testing when indicated then you are not providing optimal medical care and your patients are not receiving optimal results. If you are not using urinary serotonin and dopamine neurotransmitter testing, you are wandering in the dark as you try and treat some of your patients.

THE GOAL OF TREATMENT is to optimize the outcomes of group treatment. Individual 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa can be used to get some relief of symptoms in some patients. From day one of this project, we have used objective observations with statistical analysis to define conditions that facilitate optimal group outcomes. The concept of optimal group outcomes is at the heart of our work.

The following is inspired by a phone call from a physician last week who said, “I have been using a lot of plain 5-HTP aka 5HTP or 5 HTP (5-HTP aka 5HTP or 5 HTP) lately.” 5-HTP aka 5HTP or 5 HTP when used without dopamine precursors leads to suboptimal group results in the treatment of depression, AHDH, etc. It also depletes dopamine in long-term use. The real problem is the physician’s lack of understanding on how to treat patients with properly balanced 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa in order to achieve optimal results.

USE OF ONLY 5-HTP aka 5HTP or 5 HTP OR tyrosine aka L-tyrosine WILL NOT PROVIDE OPTIMAL GROUP RESULTS.

Ø 5-HTP aka 5HTP or 5 HTP needs to be given in proper balance with the dopamine precursors tyrosine aka L-tyrosine (n-acetyl-tyrosine aka L-tyrosine does not work) and/or L-dopa aka dopa for optimal group results

Ø Long-term use of only 5-HTP aka 5HTP or 5 HTP depletes dopamine, norepinephrine and epinephrine.

Ø Use of only 5-HTP aka 5HTP or 5 HTP does nothing to address the problems caused by or associated with dopamine dysfunction.

Ø Only about 10% to 15% of patients achieve “good” results using only 5-HTP aka 5HTP or 5 HTP.

Ø Group treatment of disease such as depression, ADHD, etc. with only 5-HTP aka 5HTP or 5 HTP is not nearly as effective as using 5-HTP aka 5HTP or 5 HTP with dopamine precursors in proper balance (in all diseases such as depression, ADHD, etc. which are caused by or associated with serotonin and/or catecholamine dysfunction).

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QUICK OVER VIEW OF TREATMENT

Urinary Neurotransmitter Testing Pearls

	At the first visit DO NOT obtain urinary serotonin and dopamine neurotransmitter testing. Simply start the patient on “level 1” 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing.
	See the “level 1” patient back in 1 week. If symptoms are not under control, increase to “level 2” 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing.
	See the “level 2” patient back in 1 week. If symptoms are not under control, increase to “level 3” 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing.

See the “level 3” patient back in 1 week. If symptoms are not under control, obtain a urinary serotonin and dopamine neurotransmitter test and follow the recommendations reported.

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The "1-2-3-Lab" Approach

Ø The tyrosine aka L-tyrosine / 5-HTP aka 5HTP or 5 HTP / L-dopa aka dopa series is only recommended for the treatment of obesity, restless leg syndrome, and Parkinsonism.

Ø Start all other patients on the 5-HTP aka 5HTP or 5 HTP/tyrosine aka L-tyrosine series.

Ø For patients who need urinary serotonin and dopamine neurotransmitter lab testing, testing will need to be ordered at the correct time and properly utilized in order to achieve relief of symptoms.

Ø Testing prior to starting 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa is of no value if the goal is relief of symptoms.

Ø Start all adult patients on the level 1 dosing.

Ø Orientate patients properly on what to do if adverse reactions occur (such as GI upset or first week problems).

Ø When the patient returns, the proper question to ask is, “How were your symptoms yesterday?” It takes 3 to 5 days for the full effects of starting or changing dosing of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing to be seen.

Ø When the patient returns, the proper question to ask is, “How were your symptoms yesterday?” It takes 3 to 5 days for the full effects of starting or changing 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing to be seen.

Ø If symptoms are not under control in one week, increase to the next dosing level or obtain a laboratory test for guidance.

Protocols have been developed and refined over the last 9 years. Deviation from these protocols should not be done unless a full understanding of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa therapy has been mastered.

Patients need to be seen weekly and 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa need to be adjusted accordingly until symptoms resolve. Failure to do so will result in prolonged suffering and an increase in treatment dropout rates.

When patients return for a visit one week after starting or changing 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing, the question to ask is “How were your symptoms yesterday?” It takes 3 to 5 days for the maximum response to occur. Therefore, the response may not be observed until day 6 (the day before the visit).

In most patients, complete relief of symptoms is like a light switch - “it is either on or off”. Some patients require several weeks of treatment during which symptoms are not relieved. Then, after several weeks with no improvements, they finally arrive at the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing where the effects of the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa turn on and the symptoms turn off.

If a patient is experiencing problems with adverse reactions or is not obtaining relief of symptoms, call NeuroResearch for a free consult at 877-626-2220.

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THE APPROACH IS SIMPLE

Adult patients should be started on the level 1 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing and return to the clinic one week later. If symptoms are not under control in one week, increase the dose to the next level. If the patient still does not have relief of symptoms after one week on the level 3 dosing, a urinary serotonin and dopamine neurotransmitter test should be obtained. At the level 3 dosing level, 50% of patients need more 5-HTP aka 5HTP or 5 HTP and 50% will need less 5-HTP aka 5HTP or 5 HTP with more dopamine precursors. While increasing the dose above level 3 empirically will give relief to some patients, the patients who do not need more than 900 mg per day of 5-HTP aka 5HTP or 5 HTP will not see results. Over half of the patients who need urinary serotonin and dopamine testing find relief of symptoms with only one urinary serotonin and dopamine neurotransmitter test. If you do not obtain urinary serotonin and dopamine neurotransmitter testing when your patient gets no relief on level 3 dosing those patients will not get optimal group results.

Use of unbalanced 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa can deplete neurotransmitter levels.

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OPTIMIZING PATIENT CARE

The goal of treatment should be to help as many patients as possible become symptom-free. Certainly, there are patients who start 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa therapy and within one week are symptoms-free. On the other end of the spectrum are patients that need two to four months of weekly care before their symptoms are under control. For these more difficult patients, there are two keys for optimal results:

ü Obtain urinary serotonin and dopamine neurotransmitter tests when indicated.

ü Obtain a free telephone consult with the NeuroResearch doctors when a patient isn’t getting better or when lab results do not correlate with clinical observations.

Labs should be ordered once the adult patient has been on the neurotransmitter dosing level 3 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing for one week with no relief of symptoms. While 80 to 85% of patients will find relief of their symptoms without urinary serotonin and dopamine lab testing, the remaining patients need their dosing adjusted with urinary serotonin and dopamine laboratory guidance. Without this dosing change, these patients will not find relief of their symptoms.

A consult is a very powerful tool when treating a difficult patient. We will do our best to correlate the laboratory results with clinical observations in ordered to recommend an 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing. In some cases, the laboratory serotonin and dopamine numbers take on a whole new meaning once we are able to compare the clinical history with the serotonin and dopamine lab results. There are indeed serotonin and dopamine laboratory “gray areas,” which can best be addressed by putting two heads together (the caregiver and the lab). If your patient is not getting better, call for a consult.

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THE NEED FOR TRAINING

THE DOCS WHO DO NOT OBTAIN PROPER TRAINING

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PROPER TREATMENT BASICS

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