NeuroResearch Clinics, Inc.

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The neurotransmitter approach used in over 900 medical clinics

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SIDE EFFECTS

Written by: Marty Hinz, MD
President Clinical Research
NeuroResearch Clinics, Inc.
Side Effect Profile

  The side effect profile of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa are similar to placebo (sugar pill) when it appears that a major side effect has occurred with starting or changing the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine and L-dopa aka dopa dosing it is usually a coincidental event. This link leads to the side effect profile for patients taking 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa with no prescription medications.

  About 1 patient in 200 will experience GI upset (upset stomach) on starting 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa. This happens in the patient who are most depleted of serotonin and dopamine neurotransmitter molecules. While this side effect is unpleasant when this happens this is the patient who needs the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa the most to replenish serotonin and dopamine neurotransmitter molecules. This link talks about strategies for managing GI upset on start up.

GI Upset On Start Up
Carbohydrate Intolerance

  Serotonin and norepinephrine neurotransmitter molecules control the appetite center of the brain. When taking 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa some patients may experience a change in the way their body reacts to certain foods (carbohydrates). This link discusses management of carbohydrate intolerance.

  20% of patients who take cysteine in the morning experience nausea for about 15 to 20 minutes. This link discusses how to manage this problem.

GI Upset From Cysteine
Drug Side Effects

  Not only do the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa allow drugs that work with serotonin, dopamine, norepinephrine, and epinephrine neurotransmitter molecules to work optimally. They may also cause the drugs work with the neurotransmitter molecules serotonin, dopamine, norepinephrine, and epinephrine to display a drug side effect. This link discusses management of drug side effects.

  The 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing protocols developed by NeuroResearch are based on analysis of huge data bases with many thousands of patients under serotonin and dopamine neurotransmitter treatment from hundreds of clinics. In doing so the goal was to maximize effectiveness and minimize side effects of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa. This link discusses the problems seen when care givers deviate from the protocols.

Amino Acid Reformulation
Paradoxical Reaction Part 1
Paradoxical Reaction Part 2
Paradoxical Reactions Part 3

  A paradoxical reaction is when the symptoms of the serotonin and dopamine neurotransmitter disease such as depression, ADHD, etc. being treated gets worse. These links discuss the proper management of paradoxical reactions so the they do not interfere with the depression, ADHD, etc. patient getting better.

  Heart burn when taking the pills is not caused by the pill but from the way the pills are taken this link discusses management of this problem.

Heartburn
Dizziness

  Dizziness is easily managed by increasing the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing. This link discusses how this works and how to manage patients with complaints of dizziness.

  When patients starting 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa complain of feeling overly tired it can be a problem. This link discusses management of this problem.

Hypersomnolence
 
 
NeuroResearch continuing medical education
 
SIDE EFFECTS

  In taking 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa there is no side effect that should require stopping on a permanent basis if managed properly. At the left links to management strategies and patient hand outs relating to side effects.

 
 
5-HTP aka 5HTP or 5 HTP 1
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neurotransmitter amino acid side effect profile

5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa
 
SIDE EFFECT PROFILE
 
No patient should have to stop serotonin and dopamine neurotransmitter therapy due to side effects, if the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa is used properly in the medical practice.
 
The follow represents over 50 patient-years of data from patients taking the serotonin and dopamine neurotransmitter precursors 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa with no drugs.
 
THE GROUP ANALYZED:
  Regarding the following side effect profile:
Ø      It is the Incidence of side effects reported at serotonin and dopamine neurotransmitter patient visits.
Ø     A database grouping of 494 serotonin and dopamine neurotransmitter patients.
Ø       It represents 1,604 serotonin and dopamine neurotransmitter patient visits.
Ø      Patients were under serotonin and dopamine neurotransmitter precursors treatment with 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa only.
Ø     Patients taking serotonin and dopamine neurotransmitter prescription drugs that might have effect on serotonin and dopamine neurotransmitter molecules were excluded.
Ø     Patients were from practices that had mastered use of serotonin and dopamine neurotransmitter precursors of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa therapy.
Ø      The data represents 50 patient-years of serotonin and dopamine neurotransmitter treatment.
 
INCIDENCE OF SIDE EFFECTS REPORTED AT > 0.2% OF VISITS.
Ø      Dry mouth ---- 34 (2.1%)
Ø      Insomnia ------ 14 (0.9%)
Ø      Headache ----- 12 (0.7%)
Ø      Nausea -------- 10 (0.6%)
Ø      Dizziness ------- 6 (0.4%)
Ø      Constipation --- 6 (0.4%)
 

INCIDENCE OF SIDE EFFECTS REPORTED AT < 0.2% OF VISITS.

Moodiness, cold extremities, cravings, diarrhea, drowsy, irritability, fingers tingle, sweats, jittery, fatigue, flatulence, palpitations, flush face, hypoglycemia, light headed, sore tongue (glossitis), depression, thirst, abdominal pain, abdominal burning, spots before eyes, non-specific dermatitis.

 

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5-HTP aka 5HTP or 5 HTP 2
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GI UPSET ON START UP

 

neurotransmitter GI upset

 
 

  GI upset (98% of start up problems) and other problems that occur on the starting of serotonin and dopamine neurotransmitter precursors 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa can be managed properly and easily. With GI upset the typical scenario is that the patient experiences GI upset with the first dose of serotonin and dopamine neurotransmitter precursors 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa. The GI upset then builds until day 3 at which point the patient quits the serotonin and dopamine neurotransmitter precursors 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa.

  From our work we know that start up GI upset occurs in the patients that are most depleted of serotonin and dopamine neurotransmitter molecules. These are the patients who need 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa therapy the most. Patients who have recently (in the last 18 to 24 months) been on certain serotonin and dopamine drugs that deplete serotonin and dopamine neurotransmitter molecules can experience this problem at an increased rate. A nutrient poor diet can also contribute to this problem as well as other mechanisms of action.

  So how is this managed properly? FIRST you need to tell all patients starting serotonin and dopamine neurotransmitter precursors 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa therapy, “If you have problems with upset stomach as you start the pills, quit the pills until you can get back into the office for instructions on how to manage the problem." Simply doing this will keep new patients from dropping out of treatment if problems with GI upset are encountered.

  When a patient returns complaining of GI upset or other start up problems the proper management is to simply cut back the dosing to one pill at bed time. Bedtime is when the patient is ready to go to sleep not ready get in bed and read a book. If patients with start up problems can take the one pill and fall asleep within 15 to 20 minutes the problems do not crop up. Patients who have experienced GI upset on start up have reported that eating one or two “soda crackers” before taking the pills at bed time also helps the problem, but we have no studies on this. After the patient has had no symptoms for 3 to 4 days, add an additional pill at bedtime and continue to increase dosing in a similar manner until the patient is on 4 pills at bed time then start adding one pill in the AM in a similar manner until the patient is at the starting dose of 8 pills a day. Once the patient is on 8 pills a day of the serotonin and dopamine neurotransmitter precursors 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing can be titrated upward as per usual with the NeuroResearch serotonin and dopamine neurotransmitter precursors treatment protocols until therapeutic serotonin and dopamine neurotransmitter levels are established as verified by urinary serotonin and dopamine neurotransmitter lab testing and clinical observations. It generally takes 3 to 4 weeks to get patients with serotonin and dopamine neurotransmitter levels up to the starting dose of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa (8 pills a day).

  From the database where the incidence of GI upset on start up is 0.5%, although we have seen practices where the incidence is much higher, such as the practice of an addictionologist or practices that were using large amounts of drugs that had a propensity for depleting serotonin and dopamine neurotransmitter molecules.

 

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5-HTP aka 5HTP or 5 HTP 3
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  In 1999 as we pushed the dosing of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa higher and got rid of prescription drugs that work with serotonin and dopamine neurotransmitter molecules from the picture in treatment we began to get reports of patients who were experiencing GI upset several weeks or months into treatment. Initially we thought this was from serotonin and dopamine neurotransmitter depletion, but it did not make sense. How could patients under treatment for several weeks or months now be experiencing serotonin and dopamine neurotransmitter depletion problems? It took us seven months of intensive serotonin and dopamine neurotransmitter patient care to find the answer. These patients all were fully adjusted out on their 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa to obtain the desired serotonin and dopamine neurotransmitter clinical response and the answer was that they were experiencing problems with “carbohydrate intolerance”. These were primarily medical weight loss patients who need higher levels of serotonin and dopamine neurotransmitter molecules and 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa to obtain the desired response. In weight loss as patients are placed in appetite suppression with prescription serotonin and norepinephrine drugs and/or 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa, in many patients the physical response is to food changes. In this case it was their response to carbohydrates. We found that it was not all carbohydrates but highly selective and usually involved just one carbohydrate. Typically the GI upset occurred in the morning about 2 to 3 hours after breakfast, although the problem could be seen anytime during the day. Most common foods were breads, noodles, and cereals, although rare cases were seen such as the woman who ate fried chicken almost every day and the problem was tracked down to the breading on the chicken. The treatment is to simply remove or change the food involved. For example, I had a 54 year old male present for a clinic visit at 10 AM who was complaining of GI upset at the clinic visit. I asked him, “What did you ear for breakfast?” He said, “Two eggs and two pieces of white bread”. I immediately said, “It is your bread.” He changed from white bread to whole wheat bread and never had another problem until a month later when he ate a piece of white bread.

CARBOHYDRATE INTOLERANCE
 

Patient Information Sheet GI Upset Carbohydrate Intolerance

 
 
 

Neurotransmitter carbohydrate intolerance

 
 
 
 

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5-HTP aka 5HTP or 5 HTP 4
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neurotransmitters and cysteine

GI UPSET FROM CYSTEINE

 

  Tyrosine aka L-tyrosine and L-dopa aka dopa deplete the sulfur amino acids if proper levels of cysteine are not administered with their use.

  All patients taking a combination of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa precursors of the serotonin, dopamine, norepinephrine and epinephrine systems need to take proper amounts of cysteine two pills three times a day to prevent depletion of the sulfur amino acid system. It has been observed in clinics that 20% of patients taking cysteine in the early morning experience GI upset. The mechanism of action of this problem is unknown but the treatment is to instruct patients at the start of treatment to take the cysteine at noon, 4 or 5 PM, and bed time. From time to time you will run into a patient who did not understand the instructions and is taking cysteine in the AM with no problems, this is fine.

   
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5-HTP aka 5HTP or 5 HTP 5
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  Drugs that work with serotonin and dopamine neurotransmitter molecules do not work if there are not enough serotonin and dopamine neurotransmitter molecules in the system to work with. Drugs that work by redistributing serotonin and dopamine neurotransmitter molecules from one place to another in the brain such as reuptake inhibitor depression and ADHD drugs deplete serotonin and dopamine neurotransmitter molecules in the long run in most patients. When this happens reuptake inhibitor depression and ADHD drugs quit working and the symptoms depression and ADHD return.

  The recommendation for depression, ADHD, etc. treatment is to simply leave the patient on any reuptake inhibitor prescription depression, ADHD, etc. drugs they may be on at initiation of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa serotonin and dopamine neurotransmitter therapy until the patient is stabilized on the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa. Another consideration exists here. As the patient with diminished effects of prescription reuptake inhibitor depression, ADHD, etc. drugs is started on 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa therapy, not only the effects of the reuptake inhibitor depression, ADHD, etc. drugs once again become fully evident, the side effects of the reuptake inhibitor depression, ADHD, etc. drugs also become evident. This occurs in approximately 3% to 5% of patients and is more prominent in patients taking a dosing of reuptake inhibitor depression, ADHD, etc. drugs that is higher than the starting dose. If patients early on in reuptake inhibitor depression, ADHD, etc. drug treatment experience symptoms not list above under side effect profile and are on other prescription drugs, the work with serotonin or dopamine neurotransmitter molecules, review the side effects of the reuptake inhibitor depression, ADHD, etc. drugs involved in the PDR. Odds are that the patient is experiencing a drug side effect and the treatment is to lower the daily dosing of the drug instead of cut back on the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing.

 

PRESCRIPTION DRUG SIDE EFFECTS

 
 
 
 

neurotransmitter drug side effects

 
 
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5-HTP aka 5HTP or 5 HTP 6
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neurotransmitter amino acid reformulation

REFORMULATION OF 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa

 

The 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa formulas with serotonin and dopamine neurotransmitter protocols of NeuroResearch were formulated for optimal group results AND to minimize side effects. Use of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa outside of the NeuroResearch guidelines is associated as an increase in side effects above those listed at the top of this web page. Also of confusion is the fact that there are 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa formulas out there for treatment of serotonin and dopamine neurotransmitter disease such as depression, ADHD, etc. that were not scrutinized properly in order to minimize side effects in clinical applications.

   
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5-HTP aka 5HTP or 5 HTP 7
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PARADOXICAL REACTIONS

 

  I received a call from a physician who reported that a weight patient started the level 1 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing and experienced a profound exacerbation of depression. In responding, the physician had changed the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing by significantly lowering the dopamine precursor, while increasing the serotonin precursor with no relief.

  The real problem was the patient was experiencing a “paradoxical reaction” - an exacerbation of depression. When starting 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa therapy with weight patients or other serotonin and dopamine neurotransmitter patients, it is not uncommon for a paradoxical reaction to occur in approximately 2 to 4% of patients. The proper approach to manage paradoxical reactions is to increase the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing of both the serotonin and dopamine precursors to the next level, then paradoxical symptoms will resolve in 1 to 2 days. Unless guided by a urinary serotonin and dopamine neurotransmitter laboratory test, it is best to use the recommended level changes and not lower the precursor dosing of one system and raise the dosing of the other.

  When faced with a paradoxical reaction, if you decrease the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing, you will not resolve the paradoxical reaction, you will simply leave your patient suffering needlessly and never get to where you need to go. Proper management of a paradoxical reaction is to increase the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing of both the dopamine and serotonin systems.

 
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5-HTP aka 5HTP or 5 HTP 8
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neurotransmitter paradoxical reactions

MORE ON PARADOXICAL SIDE EFFECTS

 
 

When serotonin and dopamine neurotransmitter precursors 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing is started or increased, some patients experience an increase in their serotonin and dopamine neurotransmitter disease symptoms such as depression, ADHD, etc. This is known as a “Paradoxical Reaction.” Some common examples of paradoxical reactions are:

Ø      Depression becomes worse.
Ø      Sleep becomes worse
Ø      The weight loss patient’s appetite increases.
Ø        Anxiety becomes worse.
Ø      Migraine headaches become worse.
  Any serotonin or dopamine related neurotransmitter dysfunction disease such as depression, ADHD, etc. can display a paradoxical reaction during treatment.

  If you encounter a paradoxical reaction in your patients, treat by increasing the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing to the next level of treatment. Physicians are trained to decrease or stop prescription serotonin and dopamine reuptake inhibitor drugs if a problem is encountered. This is exactly the opposite of what needs to be done with 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa associated paradoxical reactions.  When treating with 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa, decreasing the dose and then bringing it up slowly will greatly prolong the time that patients experience a prolonged exacerbation of symptoms, which is the wrong approach.

  In general, paradoxical reactions occur in the first week or two of serotonin and dopamine neurotransmitter treatment. However, in Parkinson patients, it is not uncommon to see paradoxical serotonin and dopamine neurotransmitter reactions occur after the patient has been treated for several weeks and dopamine is ready to inflect into the phase 3 serotonin and dopamine neurotransmitter therapeutic range. While this primarily happens with Parkinson patients, it can happen later in treatment in other serotonin and dopamine neurotransmitter patients as well.

  Paradoxical reactions indicate a need to increase the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing. When obtaining urinary serotonin and dopamine neurotransmitter testing on a patient, if you spot a paradoxical reaction, simply increase the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing. Do not wait for the results of another urinary serotonin and dopamine neurotransmitter test to be returned.

 
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5-HTP aka 5HTP or 5 HTP 9
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   A “Paradoxical reaction” is where symptoms of serotonin and dopamine neurotransmitter disease such as depression, ADHD, etc. exacerbate or get worse in the early phases of serotonin and dopamine neurotransmitter treatment as the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa is started or being adjusted. For example, a weight loss patient complains of increased hunger, a patient with migraine headaches complains of increased headaches, or a patient with depression complains of increased depression. Examples are numerous. All related to increased symptoms of serotonin and dopamine neurotransmitter disease such as depression, ADHD, etc. The knee jerk response of physicians is to lower the dose of 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa. This is exactly the opposite of what needs to be done. If you have a patient who experiences increased symptoms of serotonin and dopamine neurotransmitter disease such as depression, ADHD, etc. early on in treatment the proper treatment is to increase the 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa dosing to the next step of the serotonin and dopamine neurotransmitter treatment protocol NOT decrease the dose. In decreasing the dose and working up slowly you will subject the patient to a situation where they will experience the exacerbation of symptoms for a prolonged period of time and in all probability the patient will quit treatment.

 

PARADOXICAL REACTIONS

 
 

neurotransmitter paradoxical reaction management

 
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5-HTP aka 5HTP or 5 HTP 10
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neurotransmitter heartburn

HEARTBURN

  If a patient complains of heart burn 10 to 15 minutes after taking the serotonin and dopamine neurotransmitter precursor pills the problem is easily managed. The 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa pills are larger capsules and in some patients if they simply throw the pills in their mouth and gulp them down the pills can get stuck in the esophagus producing irritation leading to symptoms of heart burn. Management of this problem is to tell the patients to hold the pills in their mouth for 10 to 15 second with a small amount of water until the surface of the pills start to liquefy at which point the pill will slide down the esophagus into the stomach and not get stuck on the way down.

   
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5-HTP aka 5HTP or 5 HTP 11
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DIZZINESS

  If a patient complains of dizziness, the first thing to do is take a history and ask the patient, “What happened before we started treating you if you missed a meal? Did you get dizzy?” Odds are the patient will say, “Yes.” We firmly believe the problem is carbohydrate addiction. Treatment is to increase the patient to the next step of the serotonin and dopamine dosing protocol just as you would a paradoxical reaction. The mechanism of action here is complex. Discussion could easily fill more than one four page newsletter.

neurotransmitter management of dizziness
   
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5-HTP aka 5HTP or 5 HTP 13
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neurotransmitter management of tiredness

HYPERSOMNOLENCE

 

  If the patient complains of extreme tiredness on starting the serotonin and dopamine neurotransmitter precursors 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa, take a sleep history. Odds are that the patient had poor sleep prior to treatment and will have to pay back the acquired “sleep debt” prior to sleeping normal. In extreme cases have the patient start 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa on Friday if they have the weekend off and tell the patient, “Plan on sleeping all weekend to catch up on sleep."

   

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1150 88th Ave W 
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Ph. 877-626-2220 
E-Mail: Info@NeuroAssist.com 
 

DISCLAIMER: NeuroResearch is a research company that provides speakers to programs for AMA category I continuing medical education (CME) for physicians, continuing education for psychologists approved by the American Psychological Association, and licenses intellectual property for use. The NeuroResearch formulas and theory of medicine is designed for the use of combining 5-HTP aka 5HTP or 5 HTP, tyrosine aka L-tyrosine, and L-dopa aka dopa precursors of the serotonin and catecholamine systems. The formulas are intended to be used as nutritional supplements and not as a drug to treat, mitigate, treat, cure, or prevent disease.   This web site is intended to be educational purposes only. Constantly we receive e-mails from people who are not licensed health care providers. We wish we could answer them, but the new telemedicine laws that were recently legislated (and put in place) prohibit us from providing advice directly to people with no medical license or providing medical care over the Internet.