| | | | | | | | NeuroResearch Clinics, Inc. | | | AMA Category 1 | | | Continuing Medical Education |
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| | | | 5-HTP TYROSINE DOPA TREATMENT PROTOCOLS | | Written by: Marty L. Hinz, MD | | President Clinical Research | | NeuroResearch Clinics, Inc. | | Cape Coral, Florida USA Research Office |
| | | | Just Landed? | If you just landed (entered this web site via this page from a search engine) you have entered on the discussion neurotransmitter treatment protocols invented by NeuroResearch Clinics. The discussion on this page is a "support discussion" for the diseases covered on other pages. To find out what NeuroResearch Clinics is really doing click on one of the disease links at the left upper column of this web page and read about the new medical approach in treatment of the specific diseases developed by medical doctors (MDs) in Duluth, Minnesota. | NeuroResearch Clinics is a cutting edge neurotransmitter medical research project. The University of Minnesota Medical School is publishing a series of papers on the research found on this web site. The first U of MN Medical School paper was submitted for publication November 30, 2008. (To access the a copy of the first University of Minnesota Medical School paper click on the "NeuroResearch Publishing" link in the left column.) |
| | | THE 5-HTP, TYROSINE, levodopa, AND CYSTEINE POWER IN OUR HANDS |
| 5-HTP tyrosine dopa treatment protocols: When the neurotransmitters serotonin, dopamine, and norepinephrine are not high enough in the brain and the flow of electricity conducted by these neurotransmitters in the brain is not high enough symptoms of disease develop. On "The Diseases" link at the top left of this web page is a discussion of the diseases that occur when the neurotransmitter levels are not high enough in the brain. | When neurotransmitter disease such as depression, anxiety, attention deficit ADD ADHD, etc. develops the number one treatment approach in medicine today is to prescribe a reuptake inhibitor drug. It is the findings of NeuroResearch and the National Institute of Drug Abuse that reuptake inhibitor drugs deplete neurotransmitters making the cause of the problem worse, neurotransmitter levels that are not high enough to prevent disease symptoms. When drugs depletion of neurotransmitter levels are large enough the risk of suicide develops. At the left are a listing of reuptake inhibitor drugs when you click on each one the prescribing information for each drug open and displayed prominently at the top of most of the pages is a warning regarding the risk of suicide with these drugs. In addition to making the cause of the problem worse through neurotransmitter depletion these drugs are not very effective at treating depression and have a high potential to be habit forming. Go to the "Depression Drugs" link at the top left of this page for a discussion of how they cause depletion of neurotransmitters, how they are habit forming and how they are not very effective. | The 5-HTP, tyrosine, levodopa, and cysteine natural treatment protocols of NeuroResearch Clinics can be used in different ways. First they can be used to prevent neurotransmitter depletion in the brain by reuptake inhibitor drugs. They can be used to replenish neurotransmitter levels in the brain depleted by drugs or other forces. Second, the protocols can be used as a effective natural treatment modality in and of themselves without drugs. | The body and brain makes serotonin from 5-HTP. The the body and brain makes dopamine tyrosine, and dopa. Taking taking 5-HTP, tyrosine, levodopa, and cysteine is so safe that they are available in the United States over the counter without a prescription. A unique chemical property of 5-HTP and dopa is that they are synthesized by the body to serotonin and dopamine without biochemical feed back regulation. This means the more 5-HTP or dopa you take in the more serotonin or dopamine you get in you system. Based on our work with serotonin and dopamine urinary neurotransmitter testing we know that 5-HTP and dopa has the ability to establish serotonin and dopamine levels in the body far higher than is needed to relieve symptoms of any of neurotransmitter diseases such as depression, anxiety, attention deficit ADD ADHD, etc. | Common thinking in medicine is that low level neurotransmitter levels cause disease such as depression, anxiety, attention deficit ADD ADHD, etc. Yet here in the hands of every American is the very things needed to establish serotonin and dopamine neurotransmitter levels in the body and brain as high as you want. Up until the work of NeuroResearch nobody had really proven that 5-HTP, levodopa, and tyrosine are effective in natural treatment of neurotransmitter disease. All previous formal studies have not proven effectiveness of 5-HTP and/or dopa and are inconclusive at best. | The question then is, "Why have 5-HTP and dopa never been formally proven effective in the natural treatment of neurotransmitter disease such as depression, anxiety, attention deficit ADD ADHD, in scientific studies considering their ability to raise neurotransmitter levels as high as we want?" The answer: | | 5-HTP and dopa to be individualized, one size dose not fit all. Giving too much or too little 5-HTP or dopa is equally ineffective. | | 5-HTP and dopa needs to be used in proper balance (an in depth discussion of this concept is found by clicking on the "Depression Drugs" link at the top left of this page then clicking on the "Depletion" link on the right side of the page that comes up.) |
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| AMINO ACID PROTOCOL OVERVIEW | The natural protocols of NeuroResearch using 5-HTP , tyrosine, and dopa are highly effective in getting people suffering with depression off serotonin and dopamine neurotransmitter depression and attention deficit ADD ADHD drugs that work with serotonin and dopamine. 5-HTP, tyrosine, levodopa, and cysteine are effective keeping drugs working in weight loss, depression, anxiety, attention deficit ADD ADHD, and all other diseases where reuptake inhibitor drugs are prescribed. 5-HTP, tyrosine, levodopa, and cysteine excels as an alternative natural treatment to prescription drugs. Unlike depression and attention deficit ADD ADHD reuptake inhibitor drugs that do that deplete neurotransmitter levels of serotonin and dopamine in the brain, 5-HTP, tyrosine, levodopa, and cysteine when used properly increases serotonin and dopamine levels in the brain. The NeuroResearch protocols using balanced 5-HTP, tyrosine, levodopa, and cysteine increases neurotransmitter levels of serotonin and dopamine in the brain to the point where relief of symptoms is experienced. | |
| | These 5-HTP , tyrosine, and dopa protocols are highly effective but only in the hands of those that know how to use the 5-HTP , tyrosine, and dopa. If the established 5-HTP, tyrosine, levodopa, and cysteine protocols are followed we have seen 100% relief of depression, anxiety, fibromyalgia, attention deficit ADD ADHD, migraine headaches, anxiety, panic attacks, obsessive compulsive disorder, phobias, and other diseases. symptoms. |
| Taking the 5-HTP, tyrosine, levodopa, and cysteine is not like taking an aspirin where you take a pill and feel better in one half hour. It takes 3 to 5 days once the 5-HTP, tyrosine, levodopa, and cysteine are started for maximum results to be seen. In people that have experienced relief of depression, anxiety, attention deficit ADD ADHD, etc. symptoms and the symptoms return it might be from missing one or more doses of pills. From the person's perspective it appears that the pills have quit working when the real problem is missing pills. | |
| | These results are only obtained by following the 5-HTP , tyrosine, and dopa protocols. If the dosing of 5-HTP, tyrosine, levodopa, and cysteine is not adjusted properly or if serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. is not obtained when indicated the person may be left in a state with no relief of symptoms and only a bunch of medical bills to show for it. |
| tyrosine and dopa deplete the sulfur amino acids when this happens glutathione and a host of other things are depleted or not synthesized properly. A sulfur amino acid must be given in proper amounts when using tyrosine and/or dopa. The top link to the right notes loss of "total glutathione" in Parkinson people treated with dopa. We have chosen the sulfur amino acid cysteine which is the least expensive of all the sulfur amino acids. Daily dosing of the chosen sulfur amino acid needs to be 4,500 mg per day, This dosing recommendation was arrived at through objective observation with data base analysis. | |
| | PAST STUDIES OF 5-HTP, tyrosine, levodopa, and cysteine | | Using the serotonin and the dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. approach invented by NeuroResearch Clinics, Inc. in 2001 we now know the reason 5-HTP, tyrosine, levodopa, and cysteine has not proven effective in previous formal studies relates primary to flaws in the design of these serotonin and dopamine studies. | First, in looking at the dosing needs of 5-HTP, tyrosine, levodopa, and cysteine in a large group of people the individual dosing needs vary on a huge scale with some people needing very high or very low dose of 5-HTP or dopa in conjunction with very high or very low dose of the other simultaneously. Most of the previous studies simply gave a specific dose of one precursor of 5-HTP, tyrosine, levodopa, and cysteine and looked for results. | The second consideration is that 5-HTP, tyrosine, levodopa, and cysteine need to be in balance with each other for proper results. This fact takes on many considerations. In working with 5-HTP and dopa more is not always better, too much of one or too little of the other can lead to no relief of symptoms. The balance of 5-HTP, tyrosine, levodopa, and cysteine has to be just right to get the serotonin and dopamine neurotransmitter levels just right. |
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| | | N-Acetyl-tyrosine IS NOT AN EFFECTIVE PRECURSOR OF DOPAMINE | | N-acetyl-tyrosine (NAT) is synthesized from tyrosine. The equilibrium of the chemical reaction lies far toward NAT, meaning very little NAT is converted to tyrosine (the reaction that is needed if NAT is to serve as a precursor of dopa). This fact has been known in medicine for years. The practical knowledge comes from the study of kidney dialysis studies where there is a need for tyrosine replacement after dialysis. In kidney dialysis when N-acetyl-tyrosine is administered, there are no significant increase in tyrosine levels detected. | | | PHENYLALANINE IS NOT A PREDICTABLE PRECURSOR OF DOPAMINE | Phenylalanine is the precursor of tyrosine, as such it is a better precursor than NAT. The problem with phenylalanine is it is too far up the chemical pathway to be a predictable precursor for neurotransmitter synthesis. It is shuttled to other pathways and does not provide predictable clinical results. For those that attempt to use phenylalanine or N-acetyl-tyrosine as a dopamine precursor the question is, "Why?" When the effective precursors 5-HTP, tyrosine, levodopa, and cysteine are readily available. |
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| | | | 5-HTP tyrosine dopa treatment protocols | | | | | | | 5-HTP, tyrosine, levodopa, and cysteine DEPLETE DOPAMINE AND SEROTONIN IF NOT GIVEN IN PROPER BALANCE | Based on the research of NeuroResearch Clinics we realized in 1999 that using only 5-HTP depletes dopamine, and using only dopa depletes serotonin. So what does this look like from a clinical stand point when serotonin or dopamine become depleted? If serotonin or dopamine becomes too low the effects of dopa or 5-HTP respectively will no longer be seen (they quit working). | | | | | | N-acetyl-tyrosine is not a good precursor for dopamine | | NeuroResearch N-acetyl-tyrosine knowledge erroneously cited 1 | | NeuroResearch N-acetyl-tyrosine knowledge erroneously cited 2 | | | | NeuroResearch Approach | | NeuroResearch attention deficit ADD ADHD Press | | | | | | USPTO SN: 12/058338 | | USPTO SN: 11/759732 | | USPTO SN: 11/353644 | | USPTO SN: 11/353643 | | USPTO SN: 11/282965 | | USPTO SN: 10/886156 | | USPTO SN: 10/785158 | | USPTO SN: 10/715912 | | USPTO SN: 10/394597 | | USPTO SN: 09/947941 | | USPTO SN: 09/942188 | | USPTO SN: 09/943462 | | USPTO SN: 09/942370 | | USPTO SN: 09/943322 | | US Patent: 6,384,088 | | US Patent: 6,403,657 | | US Patent: 6,548,551 | | US Patent: 6,660,777 | | US Patent: 6,759,437 | | US Patent: 7,268,161 | | | | |
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5-HTP tyrosine dopa treatment protocols |
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| | APPROACHES TO THERAPY WITH 5-HTP, tyrosine, levodopa, and cysteine | | |  | | |
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| | | With regards to dosing of 5-HTP tyrosine AND dopa: | ONE SIZE DOES NOT FIT ALL | | | Simply placing people suffering with depression on a fixed dosing of 5-HTP, tyrosine, or dopa for many weeks without relief of symptoms is a waste of money and causes people suffering with depression to needlessly suffer, people suffering with depression need to have weekly adjustments of 5-HTP, tyrosine, or dopa until symptoms are under control. | | | | Individualized dosing of 5-HTP, tyrosine, levodopa, and cysteine needs to be established for each person in order for proper electrical firing of the serotonin and dopamine neurons to be established. This in turn will lead to relief of symptoms. |
| | | All too often we see care givers who continue the same dose of 5-HTP, tyrosine, or dopa after one week of natural treatment in cases where there is no relief of symptoms disease such as depression, anxiety, attention deficit ADD ADHD, etc. Continuing people on a dosing level of 5-HTP, tyrosine, levodopa, and cysteine that does not give relief of symptoms in one week will not provide relief of symptoms with further time. | | | Not ordering serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. for people not responding to natural treatment on the level 3 5-HTP, tyrosine, levodopa, and cysteine dosing fails to offer people the benefits that serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. has to offer. This leaves many people, who should be symptom free by taking 5-HTP, tyrosine, or dopa with symptoms. |
| | Therapy with 5-HTP, tyrosine, levodopa, and cysteine is optimally effective only when each individual person’s dosing needs is established. In people that are not properly responding to adjustments in the 5-HTP, tyrosine, levodopa, and cysteine dosing this involves proper adjustment of 5-HTP, tyrosine, levodopa, and cysteine doses and ordering serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. when indicated. |
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| | | SEE YOUR PEOPLE WEEKLY | There are occasional people who report complete relief of symptoms of disease such as depression, anxiety, attention deficit ADD ADHD, etc. within hours of starting 5-HTP, tyrosine, levodopa, and cysteine. Many people with depression, anxiety, attention deficit ADD ADHD, etc. obtain relief of symptoms in the first week or two (on the level 1 or level 2 dosing of 5-HTP, tyrosine, levodopa, and cysteine). | On the other end of the spectrum are those people who need 4 to 6 serotonin and dopamine urinary neurotransmitter testing assays in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. to obtain relief of symptoms (after no relief of symptoms on level 3 5-HTP, tyrosine, levodopa, and cysteine dosing for one week). It is critical to see people weekly since it will take 2 to 3 months for relief of symptoms of disease such as depression, anxiety, attention deficit ADD ADHD, etc. in the most difficult cases. If you see these people every 2 to 4 weeks while adjusting 5-HTP, tyrosine, levodopa, and cysteine, it may take 6 to 8 months for relief of symptoms of depression, anxiety, attention deficit ADD ADHD, etc. to be obtained in some people. Most people with depression, anxiety, attention deficit ADD ADHD, etc. will drop out of treatment before that happens. | | | ORDERING SEROTONIN AND DOPAMINE URINARY neurotransmitter testing WHEN INDICATED | While serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. can be ordered by the care giver at any point in natural treatment, Serotonin and dopamine baseline urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. has no correlation with the serotonin or dopamine neurotransmitter phase once the person is taking 5-HTP, tyrosine, levodopa, and cysteine. | For people not experiencing relief of symptoms on the level 3 dosing after one week, serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. should be ordered in order to chart a future natural treatment course with the 5-HTP, tyrosine, levodopa, and cysteine leading to relief of symptoms with disease such as depression, anxiety, attention deficit ADD ADHD, etc. | Based on the review of tens of thousands of serotonin and dopamine urinary neurotransmitter testing assays in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc., it is a waste of time and money to attempt to further regulate 5-HTP, tyrosine, levodopa, and cysteine dosing without obtaining serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. once the person has been on level 3 5-HTP, tyrosine, levodopa, and cysteine dosing for one week with no relief of symptoms. | | | ADJUSTING 5-HTP, tyrosine AND dopa PROPERLY | In adult people being treated for diseases such as depression, anxiety, attention deficit ADD ADHD, etc. other than obesity, Restless Leg Syndrome, or Parkinsonism - the recommendation is to increase the 5-HTP and tyrosine dosing weekly until relief of symptoms are obtained or until the level 3 dosing is in place - at which point, if relief of symptoms have not been obtain after one week, serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. should be ordered. It is not uncommon with the inexperienced care giver that the person is left on level 1 or level 2 5-HTP and tyrosine dosing for prolonged periods of time while relief of symptoms have not been obtained. This approach makes no sense, after the first week additional time will not facilitate relief of symptoms. The effects of and response to 5-HTP, tyrosine, levodopa, and cysteine is like a light switch. “It is on or off”. If relief of symptoms is not obtained in one week (at any given 5-HTP, tyrosine, levodopa, and cysteine dosing level), additional time on that dosing level will not lead to relief of symptoms. The individual dosing needs of the person leading to relief of symptoms needs to be established by properly adjusting the 5-HTP, tyrosine, levodopa, and cysteine dosing in a timely manner and ordering serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. when indicated. In people not receiving relief of symptoms one week after the level 3 dosing is prescribed, serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. should be promptly ordered. |
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| | | IN PEOPLE WHO HAVE NOT EXPERIENCED RELIEF OF SYMPTOMS AFTER ONE WEEK ON A GIVEN DOSING OF 5-HTP, tyrosine, levodopa, and cysteine: | Ø Failure to increase 5-HTP, tyrosine, levodopa, and cysteine dosing to level 3 when needed is not optimal natural treatment for depression, anxiety, attention deficit ADD ADHD, etc. | | Ø Failure to order serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. when the person has been on the level 3 dosing for one week without relief of depression, anxiety, attention deficit ADD ADHD, etc. symptoms is not optimal natural treatment. | The difference between properly adjusting 5-HTP, tyrosine, levodopa, and cysteine and ordering serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. and simply starting people with adjusting analogous to: | “Treating people properly or simply playing around with 5-HTP, tyrosine, levodopa, and cysteine.” | | | ONE SIZE DOES NOT FIT ALL | | Care givers can prescribe 5-HTP, tyrosine, levodopa, and cysteine for numerous reasons. When the goal of natural treatment is relief of symptoms, the person should be seen weekly and the 5-HTP, tyrosine, levodopa, and cysteine dosing should be adjusted weekly until symptoms of depression, anxiety, attention deficit ADD ADHD, etc. are under control. If after 21 days of natural treatment the person still has not received relief of symptoms of depression, anxiety, attention deficit ADD ADHD, etc. on level 3 dosing, serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. should be obtained in order to plot a proper individualized course of 5-HTP, tyrosine, levodopa, and cysteine dosing leading to relief of symptoms. | The problem with attempts at 5-HTP, tyrosine, levodopa, and cysteine therapy prior to our research project is still a problem with many of the “other approaches” today. “Some people get better, many do not.” Optimal relief of symptoms in people requires proper adjusting of the 5-HTP, tyrosine, levodopa, and cysteine dosing in a timely manner and ordering serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. when indicated. |
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| | | DOING IT RIGHT. | DON’T LET YOUR PEOPLE SUFFER WITH SYMPTOMS. | The most common mistake we have seen with care givers treating people for depression, anxiety, attention deficit ADD ADHD, etc. is to start 5-HTP, tyrosine, levodopa, and cysteine and leave the person on the same dose longer than one week (in some cases, several weeks or months) when there is no relief of symptoms at the end of one week. People who do not receive relief of symptoms after one week of 5-HTP, tyrosine, levodopa, and cysteine at a given dose will not obtain relief of their symptoms by prolonging the time that they stay at their current dosing level. | It takes 3 to 5 days for the maximum results of starting or changing the 5-HTP, tyrosine, levodopa, and cysteine dosing to be seen. When the person returns to clinic after one week on a given 5-HTP, tyrosine, levodopa, and cysteine dosing, the question to ask IS NOT, “How were your symptoms last week?” The question should be, “How were you symptoms yesterday?” If the person’s symptoms were not under control for most of the previous week, but were under control “yesterday” (the day before the visit), you can leave the person on the current 5-HTP, tyrosine, levodopa, and cysteine dosing and see the person back in one week to ensure symptoms are under control | | |
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| 5-HTP tyrosine dopa treatment protocols |
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| | Group Dosing Needs | | | | BEYOND THE KEY HOLE | In the past looking 5-HTP, tyrosine, levodopa, and cysteine was like looking at the other side of a door through a key hold. We see something there but results when applied to natural treatment were not effective or consistent. In retrospect, the problem was that we did not understand the dosing ranges needed in optimal natural treatment for optimal relief of symptoms. The individual dosing needs of 5-HTP, tyrosine, levodopa, and cysteine to affect relief of symptoms varies on a huge level in natural treatment. Unless you are prepared to properly establish each person’s individual 5-HTP, tyrosine, levodopa, and cysteine dosing as needed, you will not obtain optimal results with your people. |
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| 5-HTP, tyrosine, levodopa, and cysteine DOSING RANGES NEEDED FOR OPTIMAL NATURAL TREATMENT | Individual 5-HTP, tyrosine, levodopa, and cysteine dosing needs vary on a huge scale. The following are the dosing ranges for individual 5-HTP, tyrosine, levodopa, and cysteine components that are needed for optimal individual results: | | Ø 5-HTP 37.5 to 3,000 mg per day | | Ø tyrosine 375 to 12,000 mg per day | | Ø dopa 120 to 12,000 mg per day. | | It is important that 5-HTP be used in proper balance with the dopamine precursors. DO NOT use only one 5-HTP, levodopa, or tyrosine you will deplete serotonin and dopamine neurotransmitter levels. |
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| | | ESTABLISHING THE INDIVIDUAL 5-HTP, tyrosine, levodopa, and cysteine DOSING IN NATURAL TREATMENT | | The goal of natural treatment is the optimal relief of symptoms. In order to affect symptoms, each person needs to have the serotonin and catecholamine precursors 5-HTP, tyrosine, levodopa, and cysteine established in an individualized dosing level. The approach is: | | Ø Start all people on level 1 natural treatment and see them back in one week. If symptoms are not under control, adjust the 5-HTP, tyrosine, levodopa, and cysteine to levels 2 or 3, at which point most people will have found relief of symptoms. | | Ø If on level 3 the symptoms are not under control obtain serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. and follow the recommendations until symptoms resolve. | | Ø Do not prescribe over 900 mg per day of 5-HTP or 5,000 mg per day of tyrosine without serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. establishing the need to do so. | | | MISSING THE BOAT --- DO NOT USE ONLY 5-HTP | | Practicing medicine is a serious responsibility. The goal is to get diseases such as depression, anxiety, attention deficit ADD ADHD, etc. and their symptoms under control as soon as possible in all people. | If you are not using serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. when indicated then you are not providing optimal medical care and your people are not receiving optimal results. If you are not using serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc., you are wandering in the dark as you try and treat some of your people. | THE GOAL OF NATURAL TREATMENT is to optimize the outcomes of natural treatment. Individual 5-HTP, tyrosine, levodopa, and cysteine can be used to get some relief of symptoms in some people. From day one of this project, we have used objective observations with statistical analysis to define conditions that facilitate optimal group outcomes. The concept of optimal group outcomes is at the heart of our work. | The following is inspired by a phone call from a physician last week who said, “I have been using a lot of plain 5-HTP (5-HTP) lately.” 5-HTP when used without dopamine precursors leads to suboptimal group results in the natural treatment of depression, AHDH, etc. It also depletes dopamine in long-term use. The real problem is the physician’s lack of understanding on how to treat people with properly balanced 5-HTP, tyrosine, levodopa, and cysteine in order to achieve optimal results. |
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| | | USE OF ONLY 5-HTP OR tyrosine WILL NOT PROVIDE OPTIMAL GROUP RESULTS. | | Ø 5-HTP needs to be given in proper balance with the dopamine precursors tyrosine (n-acetyl-tyrosine does not work) and/or dopa for optimal group results | Ø Long-term use of only 5-HTP depletes dopamine, norepinephrine and epinephrine. | | Ø Use of only 5-HTP does nothing to address the problems caused by or associated with dopamine dysfunction. | | Ø Only about 10% to 15% of people suffering with depression achieve “good” results using only 5-HTP. | | Ø Group natural treatment of disease such as depression, anxiety, attention deficit ADD ADHD, etc. with only 5-HTP is not nearly as effective as using 5-HTP with dopamine precursors in proper balance (in all diseases such as depression, anxiety, attention deficit ADD ADHD, etc. which are caused by or associated with serotonin and/or catecholamine dysfunction). | | |
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| | | QUICK OVER VIEW OF NATURAL TREATMENT | | | | Serotonin and dopamine urinary neurotransmitter in natural treatment of depression, attention deficit ADD ADHD etc. testing pearls |  | At the first visit DO NOT obtain serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. Simply start the person on “level 1” 5-HTP, tyrosine, levodopa, and cysteine dosing. |  | See the “level 1” person back in 1 week. If symptoms are not under control, increase to “level 2” 5-HTP, tyrosine, levodopa, and cysteine dosing. |  | See the “level 2” person back in 1 week. If symptoms are not under control, increase to “level 3” 5-HTP, tyrosine, levodopa, and cysteine dosing. |
| | | See the “level 3” person back in 1 week. If symptoms are not under control, obtain serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. and follow the recommendations reported. |
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| 5-HTP tyrosine dopa treatment protocols |
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| | | | | | | | | | Ø The tyrosine, 5-HTP, and dopa formula is only recommended for the natural treatment of obesity, restless leg syndrome, and Parkinsonism. | | Ø Start all other people on the 5-HTP/tyrosine series. | | Ø For people who need serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. Testing will need to be ordered at the correct time and properly utilized in order to achieve relief of symptoms. | | Ø Serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. prior to starting 5-HTP, tyrosine, levodopa, and cysteine is of no value if the goal is relief of symptoms. |
| | Ø Start all adult people on the level 1 dosing. | | Ø Orientate people properly on what to do if adverse reactions occur (such as GI upset or first week problems). | | Ø When the person returns, the proper question to ask is, “How were your symptoms yesterday?” It takes 3 to 5 days for the full effects of starting or changing dosing of 5-HTP, tyrosine, levodopa, and cysteine dosing to be seen. | | Ø When the person returns, the proper question to ask is, “How were your symptoms yesterday?” It takes 3 to 5 days for the full effects of starting or changing 5-HTP, tyrosine, levodopa, and cysteine dosing to be seen. | | Ø If symptoms are not under control in one week, increase to the next dosing level or obtain serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. for guidance. | | |
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| | | | Protocols have been developed and refined over the last 9 years. Deviation from these protocols should not be done unless a full understanding of 5-HTP, tyrosine, levodopa, and cysteine therapy has been mastered. | People need to be seen weekly and 5-HTP, tyrosine, levodopa, and cysteine need to be adjusted accordingly until symptoms resolve. Failure to do so will result in prolonged suffering and an increase in treatment dropout rates. | When people return for a visit one week after starting or changing 5-HTP, tyrosine, levodopa, and cysteine dosing, the question to ask is “How were your symptoms yesterday?” It takes 3 to 5 days for the maximum response to occur. Therefore, the response may not be observed until day 6 (the day before the visit). | In most people, complete relief of symptoms is like a light switch - “it is either on or off”. Some people require several weeks of natural treatment during which symptoms are not relieved. Then, after several weeks with no improvements, they finally arrive at the 5-HTP, tyrosine, levodopa, and cysteine dosing where the effects of the 5-HTP, tyrosine, levodopa, and cysteine turn on and the symptoms turn off. | | | If a person is experiencing problems with adverse reactions or is not obtaining relief of symptoms, call NeuroResearch for a free consult at 877-626-2220. | | |
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| 5-HTP tyrosine dopa treatment protocols |
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| | THE APPROACH IS SIMPLE | | | Adult people should be started on the level 1 5-HTP, tyrosine, levodopa, and cysteine dosing and return to the clinic one week later. If symptoms are not under control in one week, increase the dose to the next level. If the person still does not have relief of symptoms after one week on the level 3 dosing, serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. should be obtained. At the level 3 dosing level, 50% of people need more 5-HTP and 50% will need less 5-HTP with more dopamine precursors. While increasing the dose above level 3 empirically will give relief to some people, the people who do not need more than 900 mg per day of 5-HTP will not see results. Over half of the people who need serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. find relief of symptoms with single serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. If you do not obtain serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. when your person gets no relief on level 3 dosing those people will not get optimal group results. | | | Use of unbalanced 5-HTP, tyrosine, levodopa, and cysteine can deplete neurotransmitter levels. | | |
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| | OPTIMIZING PERSON CARE | | | The goal of natural treatment should be to help as many people as possible become symptom-free. Certainly, there are people who start 5-HTP, tyrosine, levodopa, and cysteine therapy and within one week are symptoms-free. On the other end of the spectrum are people that need two to four months of weekly care before their symptoms are under control. For these more difficult people, there are two keys for optimal results: | ü Obtain serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. when indicated. | | ü Obtain a free telephone consult with the NeuroResearch doctors when a person isn’t getting better or when lab results do not correlate with clinical observations. | Labs should be ordered once the adult person has been on the neurotransmitter dosing level 3 5-HTP, tyrosine, levodopa, and cysteine dosing for one week with no relief of symptoms. While 80 to 85% of people will find relief of their symptoms without serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc., the remaining people need their dosing adjusted with serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. guidance. Without this dosing change, these people will not find relief of their symptoms. | A consult is a very powerful tool when treating a difficult person. We will do our best to correlate the laboratory results with clinical observations in ordered to recommend an 5-HTP, tyrosine, levodopa, and cysteine dosing. In some cases, the laboratory serotonin and dopamine numbers take on a whole new meaning once we are able to compare the clinical history with the serotonin and dopamine lab results. There are indeed serotonin and dopamine laboratory “gray areas,” which can best be addressed by putting two heads together (the caregiver and the lab). If your person is not getting better, call for a consult. | | |
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| 5-HTP tyrosine dopa treatment protocols |
| 5 HTP 5 |
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| | | THE NEED FOR TRAINING | | | | | | | THE DOCS WHO DO NOT OBTAIN PROPER TRAINING | | | | | | | | |
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| 5-HTP tyrosine dopa treatment protocols |
| 5 HTP 7 |
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| | PROPER NATURAL TREATMENT BASICS | | |  | | |
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| 5-HTP tyrosine dopa treatment protocols |
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| | | WHAT TO DO IF USING 5-HTP, tyrosine, levodopa, and cysteine DOES NOT WORK | | | NeuroResearch is a medical research company dedicated to providing AMA approved category I medical education to physicians in the area of 5-HTP, tyrosine, levodopa, and cysteine as applied to serotonin and dopamine neurotransmitter molecules. We have been training physicians for 7 years. 98% of the comments during technical support phone calls are positive and attest to the effectiveness of 5-HTP, tyrosine, levodopa, and cysteine therapy. Approximately 2% of the calls are from physicians complaining that the 5-HTP, tyrosine, levodopa, and cysteine are not working in natural treatment. In reviewing the 2% of phone call complaints relating to ineffective 5-HTP, tyrosine, levodopa, and cysteine in natural treatment, the following problem appears to exist in most cases - the calls are from physicians who have no training on how to use the 5-HTP, tyrosine, levodopa, and cysteine properly, as covered in our AMA certified continuing medical education seminars, hence no results. Other problems, stemming from attempting to use 5-HTP, tyrosine, levodopa, and cysteine in natural treatment without training are not adjusting 5-HTP, tyrosine, levodopa, and cysteine doses properly or not ordering serotonin and dopamine neurotransmitter lab testing at the proper time for optimal results. 5-HTP, tyrosine, levodopa, and cysteine therapy guided with serotonin and dopamine lab testing is a powerful tool, but it only works when you understand how to use it through proper training. |
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| | | The only way for this powerful tool to achieve its full potential in your hands is to first obtain proper training at one of our AMA certified continuing medical education seminars. | | |
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| 5-HTP tyrosine dopa treatment protocols |
| 5 HTP 8 |
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| | OBTAINING OPTIMAL RESULTS IN NATURAL TREATMENT WITH 5-HTP, tyrosine, levodopa, and cysteine | | | While training hundreds of care givers in techniques for optimal person outcomes in natural treatment with 5-HTP, tyrosine, levodopa, and cysteine, the three biggest problems we have seen that lead to suboptimal results are: | - Not seeing people weekly until symptoms are under control.
- Not adjusting 5-HTP, tyrosine, levodopa, and cysteine under the protocols developed.
- Not using serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. with people not responding to adjusting an 5-HTP, tyrosine, levodopa, and cysteine dosing.
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| | | GIVE YOUR PEOPLE THE BENEFITS OF A COMPLETE TRIAL OF NATURAL TREATMENT | | |
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| 5-HTP tyrosine dopa treatment protocols |
| 5 HTP 12 |
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| | THE PROPER TRIAL OF 5-HTP, tyrosine, levodopa, and cysteine | | | A proper trial of 5-HTP, tyrosine, levodopa, and cysteine only occurs when: | | 1. The person experiences relief of symptoms | | OR | | 2. The serotonin and dopamine urinary neurotransmitter testing levels in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. are in the therapeutic range AND the phase 3 response. | | On rare occasions, people achieve relief of symptoms within hours of starting the 5-HTP, tyrosine, levodopa, and cysteine. On the other end of the spectrum is people that need 2 to 3 months of weekly natural treatment to achieve relief of symptoms. | All people need to be seen weekly and have 5-HTP, tyrosine, levodopa, and cysteine dosing levels changed weekly until their symptoms are under control. Failure to see your people back weekly when relief of symptoms have not be obtained during adjustment of 5-HTP, tyrosine, levodopa, and cysteine may cause the person prolonged suffering. The delay in natural treatment may cause a person, who would normally take 2 to 3 months to stabilize, to take 6 to 8 months to get symptoms under control. | | |
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| 5-HTP tyrosine dopa treatment protocols |
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| | FOOD FOR THOUGHT | | | Avoiding Extra Hurdles. Along with working to achieve optimal group outcomes in the natural treatment of people with 5-HTP, tyrosine, levodopa, and cysteine, we have strived to perfect natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. in the most expeditious and cost effective way possible. The protocols we have developed reflect the desire to achieve optimal group outcomes in the quickest and most cost effective way. Deviation from the protocols without a thorough understanding of the consequences, in most cases, leads to suboptimal results, facilitates wasting time and wasting money. | Use of 5-HTP, tyrosine, levodopa, and cysteine to natural treatment requires proper experience and training in the basics of diagnosis, treatment, and management of the diseases such as depression, anxiety, attention deficit ADD ADHD, etc. involved. For some time I have been saying, “You take a physician who is not very good at treating depression and train them in 5-HTP, tyrosine, levodopa, and cysteine therapy, you still have a physician who is not very good at treating depression.” Formal medical training and clinical experience has to be in place for optimal results to be obtained with 5-HTP, tyrosine, levodopa, and cysteine. Several times every month we encounter care givers, who have no formal medical training in managing the disease such as depression, anxiety, attention deficit ADD ADHD, etc. they are attempting to treat with 5-HTP, tyrosine, levodopa, and cysteine. They attempt natural treatment simply because, “now they can do it since they do not need a license to write prescriptions.” This occurs despite the fact that they have no formal training in the management of the disease such as depression, anxiety, attention deficit ADD ADHD, etc. involved. This is bad medicine. | | |
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| | | CYSTEINE | | | Don’t forget the cysteine during natural treatment -- dopa and tyrosine deplete sulfur amino acids. | PERSPECTIVE: In 1997 and 1998, we were using 5-HTP, tyrosine, levodopa, and cysteine to keep prescription drugs working in weight loss. In 1999, we realized that many people lost weight just as effectively with proper use of 5-HTP, tyrosine, levodopa, and cysteine. In the process, we started taking people off prescription drugs and applying natural treatment with 5-HTP, tyrosine, levodopa, and cysteine only. Although 5-HTP, tyrosine, levodopa, and cysteine by themselves were effective in natural treatment of obesity, people who were on prescription drugs - especially phentermine, quit losing weight and had many problems when the drugs were stopped. We looked for a solution in our people. It took 9 months to find the solution. We found that by adding cysteine in proper levels with dopamine and serotonin precursors, people who had been on drugs started losing weight again. The benefit of cysteine did not show up in the database until the daily dose was at or above 3,750 mg per day. As more data arrived, it was apparent that the optimal dosing of cysteine for optimal weight loss in general was 4,500 mg per day in people (regardless of whether or not they were using prescription drugs). The benefits of cysteine were also found to be true in the natural treatment of other master neurotransmitter diseases such as depression, anxiety, attention deficit ADD ADHD, etc. | WHY CYSTEINE IS NEEDED: Cysteine (not n-acetyl-cysteine) can contribute sulfur amino acids directly into the sulfur amino acid cycle. Long-term use of dopa and tyrosine can deplete the sulfur amino acid cycle, if proper supplementation is not given. The article at the right notes a "total loss" of glutathione during natural treatment with dopa in Parkinsonism. Glutathione if a sulfur amino acid derivative. Severe depletion of the sulfur amino acids sets up conditions where dopamine starts to enter the serotonin neurons and dopamine actually becomes neurotoxic and kills off serotonin neurons. With depletion of the sulfur amino acid cycle, SAMe quits function properly. SAMe is the one carbon methyl donor of the body. It is involved with 43 major chemical reactions in the body, including the methylation of norepinephrine to epinephrine. Depletion of the sulfur amino acid cycle means that glutathione does not function properly, which leads to an increase in the risk of toxins causing damage and problems in the body. | |
| In group weight loss, the effects of cysteine when used properly are significant. Therefore, to obtain optimal group weight loss, proper cysteine supplementation is required. Cysteine is needed whenever you treat with tyrosine and/or dopa. | | |
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| 5-HTP tyrosine dopa treatment protocols |
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| | Glutathione in Old Age | | | Glutathione is our most powerful defense against toxins. Glutathione is synthesized in the body from cysteine. During life glutathione levels decline with age until people reach 80 years old at which point levels start to rise. The author of the article at the right puts forth the hypothesis that people with the lowest glutathione levels die by age 80 and this is the reason for glutathione levels increasing in people over 80, they have more glutathione. These are people over 80 where glutathione levels did not drop off prior to 80 years old. If the hypothesis is correct the solution is simple take 4,500 mg per day of cysteine with selenium. | | | | |
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| 5-HTP tyrosine dopa treatment protocols |
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| | SOME OF THE PITFALLS OF 5-HTP, tyrosine, levodopa, and cysteine IN NATURAL TREATMENT | 
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| | THE ON / OFF EFFECT OF 5-HTP, tyrosine, levodopa, and cysteine |  | | |
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| If you are not performing serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. with your people when indicated, some of your people will not receive optimal results to 5-HTP, tyrosine, levodopa, and cysteine therapy. | | |
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| | OCD PANIC ATTACKS SEVERE ANXIETY OBESITY | | | When compared to other serotonin and dopamine neurotransmitter driven diseases such as depression, anxiety, attention deficit ADD ADHD, etc., those listed above tend to require the following: | Ø A higher 5-HTP, tyrosine, levodopa, and cysteine dosing | Ø More visits to get symptoms under control | Ø More serotonin and dopamine urinary neurotransmitter testing in natural treatment of depression, anxiety, attention deficit ADD ADHD, etc. to stabilize symptoms | Certainly, there are people that have suffered from each of these diseases and found their symptoms under control with the standard starting 5-HTP, tyrosine, levodopa, and cysteine dose. But, when examining natural treatment of these diseases, these people tend to overall “need more”. | | |
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| 5-HTP tyrosine dopa treatment protocols |
| 5 HTP 19 |
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| | AN EMPIRICAL TRIAL OF 5-HTP, tyrosine, levodopa, and cysteine | | | (From Waster’s Dictionary) | EMPIRICAL | | Main Entry: em·pir·i·cal | | Variant(s): also em·pir·ic | | Function: adjective | | Date: 1569 | | 1: originating in or based on observation or experience <empirical data> 2: relying on experience or observation alone often without due regard for system and theory <an empirical basis for the theory> 3: capable of being verified or disproved by observation or experiment <empirical laws> 4: of or relating to empiricism |
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| When I started training and working in medicine during the 1970s, the old docs would talk about, “giving the person an empirical trial of natural treatment.” Now, having worked and practiced in the medical field for 35 years, I am an old doc. But, I think the whole concept of “an empirical trial” is still valid today. | As a physician, the concept of an “empirical trial of natural treatment” looks like this: after evaluation of the person’s medical history and physical findings, based solely on the experience of the physician, a course of natural treatment is prescribed without being verified by laboratory, radiological or other studies. In most cases, the term “empirical course of treatment” is applied to cases where there has been a treatment failure and the physician prescribes an alternative course of therapy based solely on past experience. | To date, we have been very careful to talk only about natural treatment results that are predictable. For example, we know from our data that in weight loss that 30% of people experience adequate appetite control on the level 1 5-HTP, tyrosine, levodopa, and cysteine dosing. | On the other side of the coin are applications where we do not have data to validate predictability of outcomes, but our first hand experience and the case studies submitted by other physicians are so compelling that an empirical trial of 5-HTP, tyrosine, levodopa, and cysteine might be considered based on these similar case results. | Under "The Diseases" tab of this web site is a case study submitted by a physician working with a person who was to be placed in an Alzheimer’s treatment facility. From what we know this outcome is possible but the predictability based on first-hand data is not there. For example, if we treat 100 people being placed in an Alzheimer’s facility, we do not know how many will respond. But the point was made by a physician that even if only 10% respond, we should be trying everyone on 5-HTP, tyrosine, levodopa, and cysteine. 5-HTP, tyrosine, levodopa, and cysteine are safe to the point of being sold over the counter, without a prescription. In addition, they have the ability to perform certain functions, which nothing else including prescription drugs can (i.e. they are the only way to increase the central nervous system levels of the master neurotransmitter molecules - serotonin, dopamine, norepinephrine, and epinephrine). | | | AN EMPIRICAL TRIAL OF NATURAL TREATMENT IS MOST JUSTIFIED WHEN THE PERSON HAS | SEVERAL FAILURES WITH TRADITIONAL TREATMENT APPROACHES. | | | When prescribing an empirical trial, it is important to follow through and adjust out the 5-HTP, tyrosine, levodopa, and cysteine dosing (with lab guidance as indicated) to the end stage. This occurs when a “resolution of symptoms” or “the lab shows the serotonin and dopamine in the therapeutic range AND phase 3 responses”. The effects of 5-HTP, tyrosine, levodopa, and cysteine therapy are like turning a light switch “on or off”. Just because the person is not responding at a given dose is not an indication to quit treatment, especially if the proper end stage has not been. For the person who has no response on the level 1 5-HTP, tyrosine, levodopa, and cysteine dosing then the dosing was increased to level 2, a dramatic response was seen. Response to 5-HTP, tyrosine, levodopa, and cysteine by people is all over the board. Some people get better by simply starting the 5-HTP, tyrosine, levodopa, and cysteine, while others require several weeks of adjusting dosages with lab guidance to obtain serotonin and dopamine in the therapeutic range and the phase 3 response before relief of symptoms are seen. |
| DON’T STOP UNTIL THE JOB IS DONE |  |
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| | | POSSIBLE EMPIRICAL TRIAL SUGGESTIONS | | Ø Dementia | | Ø Alzheimer’s | | Ø Post head injury with residual symptoms | | Ø Trouble with focus or concentration | | Ø Poison or toxin exposure with residual neurological symptoms | | Ø Autism | | Ø Tourett's Syndrome | | Ø Inappropriate aggression and anger | | Ø Cystic acne (works by hormones going in to proper balance since they are controlled by the serotonin and dopamine neurotransmitter levels.) | | Ø Any process where serotonin, dopamine, norepinephrine or epinephrine have been implicated | | |
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| If you need a medical speaker for AMA Category I CME call NeuroResearch Clinics, Inc. |
| NeuroResearch Clinics, Inc. only deals with and provides information to licensed health care professionals. |
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